18028-09-6

Basic information

• Product Name: 4-(trimethylsilyl)benzoic acid ethyl ester
• Synonyms: 4-(trimethylsilyl)benzoic acid ethyl ester
• CAS NO: 18028-09-6
• Molecular Weight: 222.359
• Mol File: 18028-09-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-(trimethylsilyl)benzoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(trimethylsilyl)benzoic acid ethyl ester(18028-09-6)
• EPA Substance Registry System: 4-(trimethylsilyl)benzoic acid ethyl ester(18028-09-6)

Safety Data

• Hazardous Substances Data: 18028-09-6(Hazardous Substances Data)

Upstream product

• 7335-27-5 ethyl 4-chlorobenzoate 
• 125261-30-5 p-(ethoxycarbonyl)phenyl triflate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 75-77-4 chloro-trimethyl-silane 
• 7153-22-2 ethyl 4-cyanobenzoate 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 75-03-6 ethyl iodide 
• 106-37-6 1.4-dibromobenzene 
• 6999-03-7 1-bromo-4-(trimethylsilyl)benzene 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 13031-45-3 ethyl 4-acetoxybenzoate 
• 76430-09-6 tris<4-(trimethylsilyl)phenyl>carbinol 
• 76430-05-2 C₂₈H₃₉Si₃^(1-) 
• 76430-10-9 tris<4-(trimethylsilyl)phenyl>methyl chloride 
• 76430-08-5 tris<4-(trimethylsilyl)phenyl>methane 

Relevant articles and documents

A flow microreactor system enables organolithium reactions without protecting alkoxycarbonyl groups

A flow microreactor system consisting of micromixers and microtube reactors provides an effective tool for the generation and reactions of aryllithiums bearing an alkoxycarbonyl group at para-, meta-, and ortho-positions. Alkyl p- and m-lithiobenzoates were generated by the I/Li exchange reaction with PhLi. The Br/Li exchange reactions with sBuLi were unsuccessful. Subsequent reactions of the resulting aryllithiums with electrophiles gave the desired products in good yields. On the other hand, alkyl o-lithiobenzoates were successfully generated by the Br/ Li exchange reaction with sBuLi. Subsequent reactions with electrophiles gave the desired products in good yields.

Diphenylphosphinophenolate: A ligand for the palladium-catalysed silylation of aryl halides activating simultaneously both palladium and silicon

Diphenylphosphinophenolate was found to be an effective ligand for the palladium-catalysed silylation of aryl halides, activating not only palladium but also silicon of a disilane, where aryl bromides and iodides having such substituents as methyl, methoxy, amino, ethoxycarbonyl, trifluoromethyl, formyl or phenyl are applicable to the reaction with hexamethyldisilane to give the corresponding trimethylsilylarenes.