1802907-92-1 Usage
Uses
Used in Bioconjugation Applications:
Methyltetrazine-PEG4-NHS Ester is used as a crosslinker for bioconjugation purposes, allowing the efficient and specific reaction with primary amines on biomolecules such as proteins or peptides. This enables the formation of stable covalent bonds, which is crucial for various applications in research and diagnostics.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Methyltetrazine-PEG4-NHS Ester is used as a component in drug delivery systems to improve the stability and solubility of therapeutic agents. The hydrophilic PEG spacer arm enhances the aqueous solubility of the drug, while the NHS ester allows for the covalent attachment of drugs to carriers or targeting moieties.
Used in Molecular Imaging:
Methyltetrazine-PEG4-NHS Ester is used as a labeling agent in molecular imaging for the conjugation of imaging probes to biomolecules. The click chemistry enabled by the methyltetrazine group allows for the specific and efficient attachment of fluorescent or radioactive tags, enabling the tracking and visualization of biological processes in vivo.
Used in Materials Science:
In the field of materials science, Methyltetrazine-PEG4-NHS Ester is used as a crosslinking agent for the development of functional materials with tailored properties. The stability and reactivity of the crosslinker allow for the creation of materials with improved mechanical, thermal, or biological performance.
Check Digit Verification of cas no
The CAS Registry Mumber 1802907-92-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,2,9,0 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1802907-92:
(9*1)+(8*8)+(7*0)+(6*2)+(5*9)+(4*0)+(3*7)+(2*9)+(1*2)=171
171 % 10 = 1
So 1802907-92-1 is a valid CAS Registry Number.
1802907-92-1Relevant academic research and scientific papers
Komatsu, Toru,Kyo, Etsu,Ishii, Haruki,Tsuchikama, Kyoji,Yamaguchi, Aiko,Ueno, Tasuku,Hanaoka, Kenjiro,Urano, Yasuteru
, p. 15644 - 15648 (2020)
We established a methodology for initiating cross-linking of antibodies selectively on the cell surface through intermolecular copper-free click reactions facilitated by increased effective concentrations of antibodies binding to target antigens. Upon cross-linking of tetrazine- and bicyclononyne-modified trastuzumab on the surface of HER2-overexpressing cells, increased antibody uptake and activation of intracellular signaling were observed. Our findings demonstrate that the cross-linking reaction can significantly alter the biophysical properties of proteins, activating their unique functionalities on targeted cells to realize an increased cargo delivery and synthetic manipulation of cellular signaling.
