180302-25-4Relevant academic research and scientific papers
Synthesis of unsymmetric cyclic urea diols, a novel class of HIV protease inhibitors
Stone, Benjamin R. P.,Harris, Gregory D.,Cann, Reginald O.,Smyser, Thomas E.,Confalone, Pat N.
, p. 6127 - 6130 (2007/10/03)
Unsymmetric cyclic urea diols of general structure 1 can be prepared either via an isourea derived from the symmetric diamine 2 or by the selective removal of a benzyl group from certain symmetric cyclic ureas 8, employing dissolving metal reduction.
Nonsymmetrically substituted cyclic urea HIV protease inhibitors
Wilkerson, Wendell W.,Dax, Scott,Cheatham, Walter W.
, p. 4079 - 4088 (2007/10/03)
A series of nonsymmetrically substituted cyclic ureacarboxamides was synthesized and evaluated for antiviral activity as a function of the inhibition of HIV-protease. Selected protease inhibitors were also evaluated for oral bioavailability. The synthesis
