180333-55-5

Upstream product

• 180333-54-4 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetaldehyde 
• 52805-34-2 4-(benzyloxy)-3-methoxybenzonitrile 
• 100-59-4 phenylmagnesium chloride 
• 96306-54-6 <3-methoxy-4-(phenylmethoxy)phenyl>phenylmethane 
• 1027201-30-4 C-(4-Benzyloxy-3-methoxy-phenyl)-C-phenyl-methyleneamine 
• 180333-53-3 2-(4-benzyloxy-3-methoxyphenyl)-2-phenyloxirane 

Downstream Products

• 180333-59-9 methyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenyl acetate 
• 1027181-42-5 (4-Benzyloxy-3-methoxy-phenyl)-phenyl-acetyl chloride 
• 180333-56-6 allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate 

Relevant academic research and scientific papers

Agents for the treatment of overactive detrusor. IX. Synthesis and pharmacological properties of metabolites of N-tert-butyl-4,4-diphenyl-2- cyclopentenylamine (FK584) in human urine

We synthesized the racemates of five presumed metabolites (1b-f) of (s)- (-)-N-tert-butyl-4,4-diphenyl-2-cyclopentenylamine hydrochloride (FK584, S(- )-1a), a novel agent for the treatment of overactive detrusor syndrome, in order to confirm the structures of the metabolites and also to evaluate their inhibitory activity against detrusor contraction. (±)-N-tert-Butyl-4-(4- hydroxyphenyl)- and 4-(4-hydroxy-3-methoxyphenyl)-4-phenyl-2-cyclopentenyl- amines (1b-e) were synthesized via 5-(4-methoxyphenyl)- and 5-(4-benzyloxy- 3-methoxyphenyl)-5-phenyl-2-cyclopenten-1-one (9g, h), respectively. Compounds 1b-f prepared in this study were identical with the metabolites in human urine in gas chromatography mass spectrometry and analytical HPLC. The inhibitory activity of compounds 1b-f against detrusor contraction in vitro induced by electrical field stimulation in guinea-pigs was less potent than that of FK584.