Benzeneacetic acid, 3-methoxy-a-phenyl-4-(phenylmethoxy)-

Base Information

• Chemical Name: Benzeneacetic acid, 3-methoxy-a-phenyl-4-(phenylmethoxy)-
• CAS No.: 180333-55-5
• Molecular Formula: C₂₂H₂₀O₄
• Molecular Weight: 348.398
• Mol file: 180333-55-5.mol

Synonyms:

Chemical Property of Benzeneacetic acid, 3-methoxy-a-phenyl-4-(phenylmethoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, 3-methoxy-a-phenyl-4-(phenylmethoxy)-

There total 6 articles about Benzeneacetic acid, 3-methoxy-a-phenyl-4-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetaldehyde (180333-54-4) → 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetic acid (180333-55-5)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tert-butyl alcohol; for 3h; Yield given; Ambient temperature;

DOI:10.1248/cpb.44.1188

Reference yield:

4-(benzyloxy)-3-methoxybenzonitrile (52805-34-2) → 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetic acid (180333-55-5)

Guidance literature:

Multi-step reaction with 5 steps

1: benzene / 1.) RT, 50 min, 2.) 70 deg C, 7 h

2: conc. aq. HCl / benzene; methanol; tetrahydrofuran / 7 h / Heating

3: 90 percent / tert-BuOK / dimethylsulfoxide / 18 h / Ambient temperature

4: 93.2 percent / BF₃*Et₂O / diethyl ether / 0.5 h / Ambient temperature

5: NaClO₂, 26percent aq. NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol / 3 h / Ambient temperature

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; boron trifluoride diethyl etherate; potassium tert-butylate; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; tert-butyl alcohol; benzene;

DOI:10.1248/cpb.44.1188

Reference yield:

phenylmagnesium chloride (100-59-4) → 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetic acid (180333-55-5)

Guidance literature:

Multi-step reaction with 5 steps

1: benzene / 1.) RT, 50 min, 2.) 70 deg C, 7 h

2: conc. aq. HCl / benzene; methanol; tetrahydrofuran / 7 h / Heating

3: 90 percent / tert-BuOK / dimethylsulfoxide / 18 h / Ambient temperature

4: 93.2 percent / BF₃*Et₂O / diethyl ether / 0.5 h / Ambient temperature

5: NaClO₂, 26percent aq. NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol / 3 h / Ambient temperature

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; boron trifluoride diethyl etherate; potassium tert-butylate; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; tert-butyl alcohol; benzene;

DOI:10.1248/cpb.44.1188

upstream raw materials:

2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetaldehyde

4-(benzyloxy)-3-methoxybenzonitrile

phenylmagnesium chloride

<3-methoxy-4-(phenylmethoxy)phenyl>phenylmethane

Downstream raw materials:

methyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenyl acetate

(4-Benzyloxy-3-methoxy-phenyl)-phenyl-acetyl chloride

allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate