307309-80-4Relevant academic research and scientific papers
Synthesis of nucleoside boranophosphoramidate prodrugs conjugated with amino acids
Li, Ping,Shaw, Barbara Ramsay
, p. 2171 - 2183 (2007/10/03)
(Chemical Equation Presented) Nucleoside boranophosphates and nucleoside amino acid phosphoramidates have been shown to be potent antiviral and anticancer agents with the potential to act as nucleoside prodrugs. A combination of these two types of compoun
Model synthesis of nucleoside boranophosphoramidate with amino acid for prodrug purpose
Li, Ping,Shaw, Barbara Ramsay
, p. 675 - 678 (2008/02/03)
A model synthesis of a nucleoside boranophosphoramidate prodrug with (L)-tryptophan methyl ester was accomplished in a one-pot reaction via an H-phosphonate approach. This new type of compound is expected to possess the potent antiviral and anticancer adv
Aryl H-Phosphonates. 12. Synthetic and 31P NMR Studies on the Preparation of Nucleoside H-Phosphonothioate and Nucleoside H-Phosphonodithioate Monoesters
Cieslak, Jacek,Jankowska, Jadwiga,Stawinski, Jacek,Kraszewski, Adam
, p. 7049 - 7054 (2007/10/03)
Transformation of nucleoside H-phosphonate monoesters into the corresponding H-phosphonothioate and H-phosphonodithioate derivatives and possible side-reactions that may accompany this process were studied using 31P NMR spectroscopy. These provided new insight into a possible mechanism involved in this transformation and constituted the basis for development of efficient methods for the preparation of nucleoside H-phosphonothioate and nucleoside H-phosphonodithioate monoesters using readily available H-phosphonate monoesters as starting materials.
