180630-37-9Relevant academic research and scientific papers
A facile synthesis of methyl 5-amino-6-chloro-2h-1-benzopyran-8-carboxylate derivatives
Kakigami, Takuji,Baba, Kunihisa,Usui, Toshinao
, p. 2611 - 2619 (1998)
Methyl 6-chloro-5-pivaloylamino-2H-1-benzopyran-8-carboxylate (4d) was prepared in good yield as a result of the thermal cylcization of methyl 5-chloro-4-pivaloylamino-2-propargyloxybenzoate (3d) using N,N-diethylaniline as a solvent.
Investigation of Synthetic Routes to a Key Benzopyran Intermediate of a 5HT4 Agonist
Rassias, Geracimos,Stevenson, Neil G.,Curtis, Neil R.,Northall, John M.,Gray, Matthew,Prodger, Jeremy C.,Walker, Andrew J.
experimental part, p. 92 - 98 (2010/04/28)
The supply route to GlaxoSmithKline's 5HT4 receptor agonist 1 centred on the construction of key benzopyran fragment 2. Our attempts to define the final manufacturing route for this component are described through a series of disconnections. The systematic approach undertaken towards the construction of the benzopyran skeleton focused on cycli- sation strategies from appropriate precursors and evaluation of the performance of the key steps.
