18068-20-7

Upstream product

• 123324-71-0 p-tert-butylphenylboronic acid 
• 75-52-5 nitromethane 
• 2396-68-1 4-t-butylbenzenethiol 
• 124-38-9 carbon dioxide 

Downstream Products

• 83719-45-3 1,1,6,6-tetrakis((p-tert-butylphenyl)thio)hexane 
• 83711-10-8 1,1-bis(phenylthio)-6,6-bis-((p-tertbutylphenyl)thio)hexane 
• 83711-06-2 1,1-bis(phenylthio)-4,4-bis((p-tert-butylphenyl)thio)butane 
• 83711-11-9 6,6-bis((p-tert-butylphenyl)thio)bicyclo<3.1.0>hexane 

Relevant academic research and scientific papers

Direct Monofluoromethylthiolation with S-(Fluoromethyl) Benzenesulfonothioate

An electrophilic shelf-stable monofluoromethylthiolating reagent S-(fluoromethyl) benezenesulfonothioate (1) was developed. In the presence of a copper catalyst, reagent 1 coupled with a variety of aryl boronic acids to give the corresponding monofluoromethylthiolated arenes in high yields. In addition, addition of reagent 1 to alkyl alkenes in the presence of a silver catalyst gave alkyl monofluoromethylthioethers in high yields.

Sc(OTf)3-Catalyzed Synthesis of Symmetrical Dithioacetals and Bisarylmethanes Using Nitromethane as a Methylene Source

Use of nitromethane as an electrophilic methylene source for the synthesis of symmetrical dithioacetals and bisarylmethanes has been showcased using Sc(OTf)3 as a catalyst. The procedure allows straightforward access to the densely functionalized dithioacetals and bisarylmethanes under mild conditions. Additionally, the method has been applied for the synthesis of antimalarial tetramethyl mellotojaponin C and anticancer dimeric phloroglucinol derivative.

Reduction of CO2 into Methylene Coupled with the Formation of C-S Bonds under NaBH4/I2 System

A selective four-electron reduction of CO2 with thiophenol using NaBH4 as a reductant is described to access dithioacetals. This reaction provides a novel synthetic method for the highly selective conversion of CO2 into methylene, and a new access to molecular structures via formation of C-S bonds using CO2 as the C1 source.