180696-12-2Relevant academic research and scientific papers
Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors
Therien, Michel,Brideau, Christine,Chan, Chi Chung,Cromlish, Wanda A.,Gauthier, Jacques Yves,Gordon, Robert,Greig, Gillian,Kargman, Stacia,Lau, Cheuk Kun,Leblanc, Yves,Li, Chun-Sing,O'Neill, Gary P.,Riendeau, Denis,Roy, Patrick,Wang, Zhaoyin,Xu, Lijing,Prasit, Petpiboon
, p. 47 - 52 (1997)
A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
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, (2008/06/13)
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
