180696-12-2Relevant articles and documents
Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors
Therien, Michel,Brideau, Christine,Chan, Chi Chung,Cromlish, Wanda A.,Gauthier, Jacques Yves,Gordon, Robert,Greig, Gillian,Kargman, Stacia,Lau, Cheuk Kun,Leblanc, Yves,Li, Chun-Sing,O'Neill, Gary P.,Riendeau, Denis,Roy, Patrick,Wang, Zhaoyin,Xu, Lijing,Prasit, Petpiboon
, p. 47 - 52 (1997)
A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
