Bioorganic and Medicinal Chemistry Letters p. 47 - 52 (1997)
Update date:2022-08-03
Topics:
Therien, Michel
Brideau, Christine
Chan, Chi Chung
Cromlish, Wanda A.
Gauthier, Jacques Yves
Gordon, Robert
Greig, Gillian
Kargman, Stacia
Lau, Cheuk Kun
Leblanc, Yves
Li, Chun-Sing
O'Neill, Gary P.
Riendeau, Denis
Roy, Patrick
Wang, Zhaoyin
Xu, Lijing
Prasit, Petpiboon
A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
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