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Usage

Uses

Used in Pharmaceutical Research:
DI-N-PROPYLAMINOACETONITRILE is used as an intermediate in the production of various pharmaceuticals, playing a crucial role in the development of new drugs.
Used in Agrochemical Production:
It is also utilized in the creation of agrochemicals, contributing to the development of products for agricultural applications.
Used in Organic Synthesis:
DI-N-PROPYLAMINOACETONITRILE is used as a building block for the creation of complex organic molecules, showcasing its versatility in organic chemistry.
Used as a Precursor in Chemical Synthesis:
It serves as a precursor in the synthesis of other important chemicals, further highlighting its value in the field of organic chemistry.

InChI:InChI=1/C8H16N2/c1-3-6-10(7-4-2)8-5-9/h3-4,6-8H2,1-2H3

Upstream product

• 10333-53-6 bis-(dipropylamino)methane 
• 50-00-0 formaldehyd 
• 151-50-8 potassium cyanide 
• 142-84-7 di-n-propylamine 
• 107-14-2 chloroacetonitrile 
• 107-16-4 glycolonitrile 
• 267220-57-5 cyanomethyl N-(cyanomethyl)piperidine-2-carboxylate 
• 7726-87-6 methacryloyloxy-acetonitrile 

Downstream Products

• 14165-22-1 N,N-dipropylethanediamine 
• 590-17-0 cyanomethyl bromide 
• 1346804-44-1 methyl 4-((2-(dipropylamino)ethyl)carbamoyl)benzoate 
• 1346804-50-9 lithium 4-((2-(dipropylamino)ethyl)carbamoyl)benzoate 
• 1346804-54-3 N₁-((5S,8S,11S)-5,8-diisobutyl-3,13-dimethyl-4,7,10-trioxo-2-oxa-3,6,9-triazatetradecan-11-yl)-N₄-(2-(dipropylamino)ethyl)terephthalamide 
• 1346804-57-6 N₁-(2-(dipropylamino)ethyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride 

Relevant academic research and scientific papers

New aldehyde and vinylsulfone proteasome inhibitors for targeted melanoma therapy

The proteasome is a promising target in cancer therapy. However, it is ubiquitous and its inhibitors cause side effects. To target melanoma cells we synthesized new peptide aldehyde and vinylsulfone inhibitors of the proteasome conjugated to the melanin-targeting ligand (MTL) derived from radiotracer [ 123I]-N-(2-diethylaminoethyl)benzamide ([123I]BZA) or [125I]-N-(4-dipropylaminobutyl)-4-iodobenzamide ([ 125I]BZ18). Influence on the cytotoxicity of the benzamide alkyl side chain length and the composition of the amino acid sequence was assessed. Among the conjugates evaluated, compound 16 and 22 presented the highest cytotoxicity (IC50, 0.71 and 0.64 μM respectively), which persisted in the presence of an MTL derived from N-(dialkylaminoalkylenyl)benzamide residue.

Syntheses of R and S isomers of AF-DX 384, a selective antagonist of muscarinic M2 receptors

Enantiomers of 5,11-dihydro-11-[2-[2-[(N,N-dipropylaminomethyl)piperidin-1-yl]ethylamino]-carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (AF-DX 384) 1, have been synthesized from (S)-(+) and (R)-(-)-2-[N,N-dipropylaminomethyl]piperidine 4. The enantiomeric excess of 1 has been determined by capillary electrophoresis by using the α-highly sulphated cyclodextrin (α-HSCD) as chiral selector within the running electrolyte. (S)-(+)-(4) was prepared from (S)-(-)-pipecolic acid in a 4-step procedure (overall yield: 30%, ee: 99%) and (R)-(-)-AF-DX 384 from (R)-(+)-pipecolic acid. The (R)-(-) isomer exhibited in vitro a 23-fold higher affinity than its enantiomer (S)-(+) towards muscarinic receptors of subtype 2. Copyright (C) 2000.