1807518-72-4

Basic information

• Product Name: Mal-PEG1-NHS ester
• Synonyms: Mal-PEG1-NHS ester;2,5-Dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate
• CAS NO: 1807518-72-4
• Molecular Formula: C13H14N2O7
• Molecular Weight: 310.25946
• Mol File: 1807518-72-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 488.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.48±0.1 g/cm3(Predicted)
• Solubility: Soluble in DCM
• PKA: -2.35±0.20(Predicted)
• CAS DataBase Reference: Mal-PEG1-NHS ester(CAS DataBase Reference)
• NIST Chemistry Reference: Mal-PEG1-NHS ester(1807518-72-4)
• EPA Substance Registry System: Mal-PEG1-NHS ester(1807518-72-4)

Safety Data

• Hazardous Substances Data: 1807518-72-4(Hazardous Substances Data)

Usage

Description

Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 760952-64-5 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoic acid 

Relevant articles and documents

Fluorogenic Behaviour of the Hetero-Diels–Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications

Fluorogenic reactions are largely underrepresented in the toolbox of chemoselective ligations despite their tremendous potential, particularly in chemical biology and biochemistry. In this respect, we have investigated in full detail the fluorescence behaviour of the azaphthalamide, a scaffold which is generated through a hetero-Diels–Alder reaction of 5-alkoxyoxazole and maleimide derivatives under mild conditions that are compatible with, among others, peptide chemistry. The scope and limitations of such a fluorogenic labelling strategy were examined through four distinct applications, which target enzymatic activities or bioorthogonal reactions.