1807518-72-4 Usage
Uses
Used in Bioconjugation:
Mal-PEG1-NHS ester is used as a bioconjugation agent for the attachment of thiol-containing biomolecules to amine-containing molecules. This is achieved through the reaction of the maleimide group with the thiol group and the NHS ester with the amine group, forming stable covalent bonds.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Mal-PEG1-NHS ester is used as a component in drug delivery systems to improve the solubility, stability, and targeting of therapeutic agents. The PEG spacer can enhance the bioavailability and circulation time of drugs in the body, while the reactive groups allow for the attachment of drugs or other targeting moieties to the carrier system.
Used in Diagnostic Imaging:
In the field of diagnostic imaging, Mal-PEG1-NHS ester is used as a contrast agent or a component of contrast agents. The PEG spacer can improve the pharmacokinetics and biodistribution of imaging agents, while the reactive groups enable the attachment of imaging moieties or targeting ligands to the carrier system.
Used in Biosensor Development:
Mal-PEG1-NHS ester is utilized in the development of biosensors as a means to immobilize enzymes, antibodies, or other recognition elements onto sensor surfaces. The PEG spacer can provide a hydrophilic environment that reduces non-specific interactions, while the reactive groups allow for the covalent attachment of the biomolecules to the sensor surface.
Check Digit Verification of cas no
The CAS Registry Mumber 1807518-72-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,7,5,1 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1807518-72:
(9*1)+(8*8)+(7*0)+(6*7)+(5*5)+(4*1)+(3*8)+(2*7)+(1*2)=184
184 % 10 = 4
So 1807518-72-4 is a valid CAS Registry Number.
1807518-72-4Relevant academic research and scientific papers
Fluorogenic Behaviour of the Hetero-Diels–Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications
Renault, Kévin,Jouanno, Laurie-Anne,Lizzul-Jurse, Antoine,Renard, Pierre-Yves,Sabot, Cyrille
, p. 18522 - 18531 (2016/12/16)
Fluorogenic reactions are largely underrepresented in the toolbox of chemoselective ligations despite their tremendous potential, particularly in chemical biology and biochemistry. In this respect, we have investigated in full detail the fluorescence behaviour of the azaphthalamide, a scaffold which is generated through a hetero-Diels–Alder reaction of 5-alkoxyoxazole and maleimide derivatives under mild conditions that are compatible with, among others, peptide chemistry. The scope and limitations of such a fluorogenic labelling strategy were examined through four distinct applications, which target enzymatic activities or bioorthogonal reactions.
