180900-85-0Relevant articles and documents
Imidazo[1,2-b]pyridazines. XIX syntheses and central nervous system activities of some 6-arylthio(aryloxy and alkylthio)-3(acetamidomethyl, benzamidomethyl, methoxy and unsubstituted)-2-arylimidazo[1,2-b]pyridazines
Barlin, Gordon B.,Davies, Les P.,Ireland, Stephen J.
, p. 443 - 449 (2007/10/03)
Some 6-arylthio(aryloxy and alkylthio)-3-(acetamidomethyl, benzamidomethyl, methoxy and unsubstituted)-2-arylimidazo[1,2-b]pyridazines have been prepared and examined for their ability to displace [3H]diazepam from rat brain membranes. The most active compound was 3-acetamidomethyl-2-(3′,4′-methylenedioxyphenyl)-6- phenylthioimidazo[1,2-b]pyridazine with IC50 4.4 nM. The 3-acylaminomethyl-6-(2- and 3-methoxyphenylthio)-2-phenylimidazo[1,2-b]pyridazines proved less active than their 6-phenylthio analogues, and larger substituants at the 2- and 6-positions markedly decreased binding. Significant differences in binding ability have been observed between 3-acylaminomethyl-2-aryl-6-phenylthioimidazo[1,2-b]pyridazines and the corresponding imidazo[1,2-a]pyridines.