180900-96-3

Basic information

• Product Name: 6-(2-Methoxy-phenylsulfanyl)-2-phenyl-imidazo[1,2-b]pyridazine
• Synonyms: 6-(2-Methoxy-phenylsulfanyl)-2-phenyl-imidazo[1,2-b]pyridazine
• CAS NO: 180900-96-3
• Molecular Weight: 333.414
• Mol File: 180900-96-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(2-Methoxy-phenylsulfanyl)-2-phenyl-imidazo[1,2-b]pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2-Methoxy-phenylsulfanyl)-2-phenyl-imidazo[1,2-b]pyridazine(180900-96-3)
• EPA Substance Registry System: 6-(2-Methoxy-phenylsulfanyl)-2-phenyl-imidazo[1,2-b]pyridazine(180900-96-3)

Safety Data

• Hazardous Substances Data: 180900-96-3(Hazardous Substances Data)

Upstream product

• 7217-59-6 2-Methoxybenzenethiol 
• 70-11-1 α-bromoacetophenone 
• 180900-85-0 6-(2-Methoxy-phenylsulfanyl)-pyridazin-3-ylamine 

Relevant articles and documents

Imidazo[1,2-b]pyridazines. XIX syntheses and central nervous system activities of some 6-arylthio(aryloxy and alkylthio)-3(acetamidomethyl, benzamidomethyl, methoxy and unsubstituted)-2-arylimidazo[1,2-b]pyridazines

Some 6-arylthio(aryloxy and alkylthio)-3-(acetamidomethyl, benzamidomethyl, methoxy and unsubstituted)-2-arylimidazo[1,2-b]pyridazines have been prepared and examined for their ability to displace [3H]diazepam from rat brain membranes. The most active compound was 3-acetamidomethyl-2-(3′,4′-methylenedioxyphenyl)-6- phenylthioimidazo[1,2-b]pyridazine with IC50 4.4 nM. The 3-acylaminomethyl-6-(2- and 3-methoxyphenylthio)-2-phenylimidazo[1,2-b]pyridazines proved less active than their 6-phenylthio analogues, and larger substituants at the 2- and 6-positions markedly decreased binding. Significant differences in binding ability have been observed between 3-acylaminomethyl-2-aryl-6-phenylthioimidazo[1,2-b]pyridazines and the corresponding imidazo[1,2-a]pyridines.