180901-61-5

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 90145-13-4 N-(α-Bromobenzylidene)-N'-methylhydrazine hydrobromide 
• 60-34-4 methylhydrazine 
• 5873-90-5 methyl benzimidate hydrochloride 
• 82507-66-2 1,4,5-trihydro-3-pheny<1,2,4>triazin-6(2H)-one 
• 74-88-4 methyl iodide 
• 7471-86-5 methyl benzimidate 

Downstream Products

• 260542-26-5 1-methyl-3-phenyl-1,2,4-triazin-6(1H)-one 
• 39696-58-7 1-methyl-3-phenyl-1H-1,2,4-triazole 
• 1338470-26-0 1-methyl-3-phenyl-4,5-dihydro-1,2,4-triazin-6-thione 
• 1338470-34-0 4,6-dimethyl-2,8-diphenyl-1-thia-3,4,6,7,9-pentaazaspiro[4.5]dec-2,7-diene 

Relevant academic research and scientific papers

Dihydro-1,2,4-triazin-6(1H)-ones. II synthesis of several methylated 3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-ones

Novel syntheses of 4,5-dihydro-1,2,4-triazin-6(1H)-ones were developed by use of imidoyl chlorides. The overall yield of 4,5-dihydro-1,2,4-triazin-6(1H)-ones prepared from amino acid imidates and hydrazines was improved by the development of a much more efficient synthesis of the imidates. The new 1,2-, 1,4- and 5,5-dimethyl dihydro-1,2,4-triazin-6(1H)-ones have been synthesized by cyclocondensation/cycloaddition pathways. Base-catalysed methylation of 3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one (15) gave the 1-methylated derivative (8); under similar conditions 2-methyl-3-phenyl-2,5-dihydro-1,2,4-triazin-6(1H)-one (9) afforded the 1,2-dimethyl derivative (7).

Regiospecific syntheses of the monomethylated 3-phenyldihydro-1,2,4-triazin-6(1H)-ones

Unambiguous syntheses of four unreported monomethylated derivatives of 3-phenyldiliydro-1,2,4-triazin-6(1H)-ones, namely, the 1-methyl (2), 2-methyl (3), 4-methyl (4) and the imidic O-methyl derivative (5), are described. Regioselectivity was achieved for