82507-66-2 Usage
Description
3-Phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one, commonly known as Phenidone, is a white solid chemical compound with the molecular formula C9H9N3O and a molar mass of 175.19 g/mol. It is a potent and selective inhibitor of DNA topoisomerase II, an enzyme that plays a crucial role in DNA replication and transcription. Phenidone is widely used in various applications, including the photographic industry as a developer and as a reagent in the synthesis of pharmaceuticals and other organic compounds.
Uses
Used in Photographic Industry:
3-Phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one is used as a developer in the photographic industry for its ability to enhance the image quality and improve the development process of photographic films and papers.
Used in Pharmaceutical Synthesis:
3-Phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one is used as a reagent in the synthesis of pharmaceuticals and other organic compounds due to its unique chemical properties and its ability to selectively inhibit DNA topoisomerase II.
Used in Research Applications:
3-Phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one is used as a research tool in the study of DNA replication and transcription processes, as well as in the investigation of the role of DNA topoisomerase II in various biological processes.
Safety Precautions:
It is important to handle 3-Phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one with caution, as it is considered hazardous. It can cause skin and eye irritation, and may have harmful effects if swallowed or inhaled. Proper safety measures, such as wearing protective clothing and using appropriate handling techniques, should be followed to minimize potential risks.
Check Digit Verification of cas no
The CAS Registry Mumber 82507-66-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,5,0 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 82507-66:
(7*8)+(6*2)+(5*5)+(4*0)+(3*7)+(2*6)+(1*6)=132
132 % 10 = 2
So 82507-66-2 is a valid CAS Registry Number.
82507-66-2Relevant articles and documents
Solid-phase synthesis of functionalized 1,2,4-triazin-6-ones
Blass, Benjamin E,Coburn, Keith R,Faulkner, Amy L,Liu, Song,Ogden, Adam,Portlock, David E,Srivastava, Anil
, p. 8165 - 8167 (2002)
The solid supported synthesis of functionalized 1,2,4-triazin-6-ones from resin bound amino acids and acid chlorides is described. A thioamide intermediate is generated with Lawesson's reagent, and the final products are cyclized and cleaved from resin with hydrazine. The products are obtained in good yield and purity.
Synthesis of 1,2,4-Triazines, XV. - Synthesis of 1,2,4-Triazin-6(1H)-ones
Neunhoeffer, Hans,Klein-Cullmann, Birgit
, p. 1271 - 1274 (2007/10/02)
1,2,4-Triazin-6(1H)-ones 3 have been prepared by cyclization of α-ketoacyl chlorides 15 with amidrazones 14. 4,5-Dihydro-1,2,4-triazin-6(1H)-ones 5 were obtained by cyclization of amino acid hydrazides 10 with orthocarboxylates 11.Key Word: 1,2,4-Triazin-
