82507-66-2

Usage

Uses

Used in Photographic Industry:
3-Phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one is used as a developer in the photographic industry for its ability to enhance the image quality and improve the development process of photographic films and papers.
Used in Pharmaceutical Synthesis:
3-Phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one is used as a reagent in the synthesis of pharmaceuticals and other organic compounds due to its unique chemical properties and its ability to selectively inhibit DNA topoisomerase II.
Used in Research Applications:
3-Phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one is used as a research tool in the study of DNA replication and transcription processes, as well as in the investigation of the role of DNA topoisomerase II in various biological processes.
Safety Precautions:
It is important to handle 3-Phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one with caution, as it is considered hazardous. It can cause skin and eye irritation, and may have harmful effects if swallowed or inhaled. Proper safety measures, such as wearing protective clothing and using appropriate handling techniques, should be followed to minimize potential risks.

Upstream product

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Downstream Products

• 180901-68-2 6-chloro-3-phenyl-4,5-dihydro-1,2,4-triazine 
• 84586-28-7 3-phenyl-1,2,4-triazinone 
• 289622-86-2 3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-thione 
• 180901-61-5 1-methyl-3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one 

Relevant academic research and scientific papers

Solid-phase synthesis of functionalized 1,2,4-triazin-6-ones

The solid supported synthesis of functionalized 1,2,4-triazin-6-ones from resin bound amino acids and acid chlorides is described. A thioamide intermediate is generated with Lawesson's reagent, and the final products are cyclized and cleaved from resin with hydrazine. The products are obtained in good yield and purity.

Dihydro-1,2,4-triazin-6(1H)-ones. II synthesis of several methylated 3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-ones

Novel syntheses of 4,5-dihydro-1,2,4-triazin-6(1H)-ones were developed by use of imidoyl chlorides. The overall yield of 4,5-dihydro-1,2,4-triazin-6(1H)-ones prepared from amino acid imidates and hydrazines was improved by the development of a much more efficient synthesis of the imidates. The new 1,2-, 1,4- and 5,5-dimethyl dihydro-1,2,4-triazin-6(1H)-ones have been synthesized by cyclocondensation/cycloaddition pathways. Base-catalysed methylation of 3-phenyl-4,5-dihydro-1,2,4-triazin-6(1H)-one (15) gave the 1-methylated derivative (8); under similar conditions 2-methyl-3-phenyl-2,5-dihydro-1,2,4-triazin-6(1H)-one (9) afforded the 1,2-dimethyl derivative (7).

Synthesis of 1,2,4-Triazines, XV. - Synthesis of 1,2,4-Triazin-6(1H)-ones

1,2,4-Triazin-6(1H)-ones 3 have been prepared by cyclization of α-ketoacyl chlorides 15 with amidrazones 14. 4,5-Dihydro-1,2,4-triazin-6(1H)-ones 5 were obtained by cyclization of amino acid hydrazides 10 with orthocarboxylates 11.Key Word: 1,2,4-Triazin-

Herbicidal triazinones

1,2,4-Triazin-6(1H)-ones, useful as herbicides.