180979-76-4

Upstream product

• 100-39-0 benzyl bromide 
• 180794-81-4 (+)-6-O-benzyl-2,3-O-cyclohexylidene-1-O-(p-methoxybenzyl)-myo-inositol 
• 41545-19-1 (+)-1,2:5,6-di-O-cyclohexylidene-myo-inositol 
• 180794-80-3 (-)-6-O-benzyl-2,3:4,5-di-O-cyclohexylidene-1-O-(p-methoxybenzyl)-myo-inositol 
• 124601-98-5 (-)-6-O-benzyl-2,3:4,5-di-O-cyclohexylidene-myo-inositol 

Downstream Products

• 180794-84-7 (-)-2,4,5,6-tetra-O-benzyl-myo-inositol 3-(dibenzyl phosphate) 
• 180979-78-6 (-)-3-O-allyl-4,5,6-tri-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 
• 180794-82-5 (+)-3-O-allyl-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 
• 141040-56-4 (+)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 
• 180794-83-6 (-)-2,4,5,6-tetra-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 3-(dibenzyl phosphate) 
• 180979-77-5 (+)-4,5,6-tri-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 

Relevant academic research and scientific papers

Synthesis of the D-3 series of phosphatidylinositol phosphates

The 3-mono-, 3,4-bis-, and 3,4,5-trisphosphates of L-α-phosphatidyl-D-myo-inositol have been synthesized in their optically active forms from the two enantiomers of 1,2:5,6-di-O-cyclohexylidene-myo-inositol. These chiral precursors were prepared by a facile biocatalytic resolution, in which the 4-butyryl ester of the racemic compound was subjected to enantioselective hydrolysis by porcine pancreatic lipase in a biphasic system. The overall yield from individual chiral precursors ranged from 32% for the 3,4,5-trisphosphate to 39% for the monophosphate.