124601-98-5Relevant academic research and scientific papers
Synthesis of substrate analogues as potential inhibitors for Mycobacterium tuberculosis enzyme MshC
Patel, Krishnakant,Song, Fengling,Andreana, Peter R.
, p. 10 - 18 (2017/11/07)
Mycothiol cysteine ligase (MshC) is a key enzyme in the mycothiol (MSH) biosynthesis and a promising target for developing new anti-mycobacterial compounds. Herein, we report on the synthesis of substrate analogues, as potential inhibitors, for the MshC e
Inositol-phosphate derivatives and method of detecting inositol-1-phosphate
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, (2012/05/20)
The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule
Total synthesis and proof of structure of mycothiol bimane
Nicholas, Gillian M.,Kovac, Pavol,Bewley, Carole A.
, p. 3492 - 3493 (2007/10/03)
Mycothiol is a low-molecular weight thiol produced by actinomycetes that serves to protect these organisms from oxidative stress and alkylating agents. We report the total synthesis of mycothiol bimane (1) which is a commonly isolated derivative of mycoth
Synthesis of the D-3 series of phosphatidylinositol phosphates
Wang, Da-Sheng,Chen, Ching-Shih
, p. 5905 - 5910 (2007/10/03)
The 3-mono-, 3,4-bis-, and 3,4,5-trisphosphates of L-α-phosphatidyl-D-myo-inositol have been synthesized in their optically active forms from the two enantiomers of 1,2:5,6-di-O-cyclohexylidene-myo-inositol. These chiral precursors were prepared by a facile biocatalytic resolution, in which the 4-butyryl ester of the racemic compound was subjected to enantioselective hydrolysis by porcine pancreatic lipase in a biphasic system. The overall yield from individual chiral precursors ranged from 32% for the 3,4,5-trisphosphate to 39% for the monophosphate.
Modulation of the inositol 1,4,5-trisphosphate receptor by inositol phosphates
Lu, Pei-Jung,Chen, Ching-Shih
, p. 325 - 328 (2007/10/03)
The mode of recognition at the binding site of the Ins(1,4,5)P3 receptor was assessed by examining the structure-activity relationships of different Ca2+-mobilizing inositol phosphates.
Studies related to synthesis of glycophosphatidylinositol membrane-bound protein anchors. 6. Convergent assembly of subunits
Madsen, Robert,Udodong, Uko E.,Roberts, Carmichad,Mootoo, David R.,Konradsson, Peter,Fraser-Reid, Bert
, p. 1554 - 1565 (2007/10/02)
Glycophosphatidylinositol anchors of membrane-bound proteins are thought to comprise a common pentasaccharide core containing mannan, glucosamine, and inositol residues. A synthetic route to this core is described. In addition, the complete heptasaccharide moiety of the rat brain Thy-1 membrane anchor, the first mammalian membrane anchor to be characterized, has been synthesized. In the case of the Thy-1 anchor, the synthetic plan is based on three building blocks comprising glucosamine-inositol, galactosamine-mannose, and trimannan residues. Although glycosyl donors other than n-pentenyl glycosides (NPGs) have been used in preparing each of these building blocks, the final assembly of the heptasaccharide utilizes NPGs as the only glycosyl donors. The mildness of the conditions for these coupling reactions has allowed us to make provisions for subsequent installation of the three phosphodiester units.
Synthesis of (+/-) Myo-Inositol-1-O-Methylphosphonate-4,5-Bis(phosphate), an Analogue of D-Myo-Inositol-1,4,5-Tris(phosphate).
Schmitt, Laurent,Spiess, Bernard,Schlewer, Gilbert
, p. 7059 - 7060 (2007/10/02)
The synthesis of (+/-) myo-inositol-1-O-methylphosphonate-4,5-bis(phosphate) is reported.This compound is analogue of D-myo-inositol-1,4,5-tris(phosphate) in which the phosphate group in position 1 is replaced by a methyl phosphonate function and where the important vicinal phosphate groups in positions 4 and 5 are preserved.
SYNTHESIS, POTENTIOMETRIC AND 31P-NMR INVESTIGATIONS OF THE IONIZATION STATE AND COMPLEXATION PROPERTIES OF INOSITOL-PHOSPHATES: BIOLOGICAL CONSEQUENCES
Schmitt, Laurent,Bortmann, Patrick,Spiess, Bernard,Schlewer, Gilbert
, p. 147 - 150 (2007/10/02)
The synthesis and the potentiometric studies of inositol-phosphates allow, particularly for Ins(1,4,5)P3, the correlation between the ionization state of the phosphate functions and the binding properties of the inositol-phosphates.
Synthesis and Tritium Radiolabelling of Fluorinated Analogues of myo-Inositol
Offer, John L.,Voorheis, H. Paul,Metcalfe, James C.,Smith, Gerry A.
, p. 953 - 960 (2007/10/02)
Syntheses have been developed for a set of six myo-inositol analogues from myo-inositol in which single hydroxy groups have been replaced by fluorine (monodeoxy-fluoro-myo-inositols).Except for 2-deoxy-2-fluoro-myo-inositol 32 and 1D-4-deoxy-4-fluoro-myo-
An efficient chemoenzymic access to optically active myo-inositol polyphosphates
Gou,Liu,Chen
, p. 51 - 64 (2007/10/02)
The 1,4,5-tris-, 1,3,4-tris-, and 1,3,4,5-tetrakis-phosphates of 1D-myo-inositol have been prepared in their enantiomerically pure forms from the two enantiomers of 1,2:5,6-di-O-cyclohexylidene-myo-inositol. A facile enzymic preparation is also described
