98645-45-5

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-4-ethoxynicotinonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex organic compounds that possess therapeutic properties.
Used in Agrochemical Industry:
2-chloro-4-ethoxynicotinonitrile is used as a precursor in the production of nicotinoyl chloride, which is an important building block for the synthesis of various organic compounds, including those with pesticidal properties.
Used in Insecticide Preparation:
2-chloro-4-ethoxynicotinonitrile is used as an active ingredient in the preparation of insecticides, leveraging its pesticidal properties to control and manage insect populations.
Used in Herbicide Preparation:
Similarly, in the herbicide industry, 2-chloro-4-ethoxynicotinonitrile is utilized for its ability to contribute to the development of compounds that effectively control, prevent, or kill unwanted plant species in agricultural settings.

InChI:InChI=1/C8H7ClN2O/c1-2-12-7-3-4-11-8(9)6(7)5-10/h3-4H,2H2,1H3

Upstream product

• 869802-74-4 2-chloro-3-cyano-4-hydroxypyridine 
• 64-17-5 ethanol 
• 180995-12-4 2,4-dichloro-3-cyanopyridine 
• 74-96-4 ethyl bromide 
• 95689-38-6 1,1-dicyano-4-(N,N-dimethylamino)-2-methoxy-1,3-butadiene 
• 98645-41-1 1,1-Dicyan-4-(N,N-dimethylamino)-2-ethoxy-1,3-butadien 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 

Downstream Products

• 98645-47-7 4-Ethoxypyridin-3-carbonitril 
• 609-70-1 4-hydroxynicotinic acid 
• 635731-97-4 2-bromo-3-cyano-4-hydroxypyridine 
• 869802-74-4 2-chloro-3-cyano-4-hydroxypyridine 

Relevant academic research and scientific papers

An efficient method for the preparation of 4-alkoxy-substituted thieno[2,3-b]pyridines

An efficient method for the preparation of 4-alkoxy-substituted thieno[2,3-b]pyridines is described. The key intermediates, 4-alkoxy-2-chloro-3- cyanopyridines, were synthesized from a variety of alcohols by nucleophilic substitution with 3-cyano-2,4-dich

The discovery of thienopyridine analogues as potent IκB kinase β inhibitors. Part II

An SAR study that identified a series of thienopyridine-based potent IκB Kinase β (IKKβ) inhibitors is described. With focuses on the structural optimization at C4 and C6 of structure 1 (Fig. 1), the study reveals that small alkyl and certain aromatic groups are preferred at C4, whereas polar groups with proper orientation at C6 efficiently enhance compound potency. The most potent analogues inhibit IKKβ with IC50s as low as 40 nM, suppress LPS-induced TNF-α production in vitro and in vivo, display good kinase selectivity profiles, and are active in a HeLa cell NF-κB reporter gene assay, demonstrating that they directly interfere with the NF-κB signaling pathway.

THIENOPYRIDINE DERIVATIVES

The present invention provides a compound promoting osteogenesis. The present invention provides a compound having the following general formula (I) wherein R 1 is H or alkyl, R 2 is R a S-, R a O-, R a NH-, R a (R b )N- or cyclic amino, and R a and R b are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.

ANTAGONISTS OF THE MGLU RECEPTOR AND USES THEREOF

The present invention discloses compounds of general formula (I) wherein X1-X4 and R1-R3 are as defined in the description. The present invention also discloses methods of treatment for pain, neurodegeneration and convulsive states in a host mammal in need thereof, and pharmaceutical compositions including those compounds.

Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists

SAR (structure-activity relationship) studies of triazafluorenone derivatives as potent mGluR1 antagonists are described. The triazafluorenone derivatives are non-amino acid derivatives and noncompetitive mGluR1 antagonists that bind at a putative alloste