1810-74-8

Usage

Uses

Used in Pharmaceutical Industry:
7-Methoxy-2,2,4-trimethyl-1,2-dihydroquinoline is used as an anti-inflammatory agent for its potential therapeutic effects in reducing inflammation and associated conditions.
Used in Chemical and Material Science:
7-Methoxy-2,2,4-trimethyl-1,2-dihydroquinoline is used as a key component in the preparation of fluorescent dyes, which are essential for various applications in the field of biological microscopy and nanoscopy. Its unique properties enable the development of advanced imaging techniques and tools for scientific research and diagnostics.

Upstream product

• 536-90-3 m-Anisidine 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 67-64-1 acetone 
• 74-99-7 prop-1-yne 
• 104-15-4 toluene-4-sulfonic acid 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 4286-55-9 1-bromo-6-hexanol 

Downstream Products

• 1211325-03-9 10-methoxy-5,5,7-trimethyl-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline 
• 179898-22-7 7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline 
• 63095-11-4 (R/S)-1,2,3,4-tetrahydro-7-hydroxy-2,2,4-trimethylquinoline 
• 1448822-28-3 C₁₈H₂₇NO₃ 
• 66876-12-8 2,2-dimethyl-7-methoxy-4-phenyl dihydroquinoline 
• 150749-29-4 N-ethyl-7-methoxy-2,2,4-trimethyl-1,2-dihydroquinoline 
• 41381-73-1 7-methoxy-2,2,4-trimethyl-1,2-dihydroquinoline 
• 186604-44-4 7-methoxy-6-tricyanovinyl-1,2-dihydro-2,2,4-trimethylquinoline 
• 326801-99-4 5,5,7-trimethyl-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinolin-10-ol 

Relevant academic research and scientific papers

Efficient green coumarin dopants for organic light-emitting devices

We have synthesized a new green fluorescent dopant C-545P having incorporated five strategically placed "methyl" steric spacers on the julolidyl ring system. C-545P has good thermal properties and photostability, and when fabricated as a dopant in an Alq3-hosted OLED device, it shows notable improvement in luminance efficiency and is more resistant to concentration quenching than C-545T, particularly in the doping concentration range between 1 and 2% v/v, while achieving comparable device stability.

The synthesis and first full structural elucidation of a benzotriazole azo dye

Although azo dyes containing benzotriazole are of interest as substrates for surface enhanced resonance Raman scattering, SERRS, little is known of their molecular structure due to their poor crystal growth properties. We recently synthesised a highly crystalline dihydroquinoline via an unusual condensation reaction and we report herein that the azo-benzotriazole dye subsequently formed was sufficiently crystalline to allow structural elucidation using synchroton radiation. It was found that this benzotriazole dye exists as the unexpected 6-isomer and the structure of the dihydroquinoline moiety changes markedly on coupling due to increased delocalisation.

7-methoxy-2,2,4-trimethyl-1,2-dihydroquinoline

The title compound, C13H17NO, was prepared using a new class of activator, alkyl bromides. The heterocyclic ring adopts a non-planar conformation, which contrasts with the conformations found for related compounds.

Rhodamine analogs for molecular ruler applications

A series of geometrically well-defined cationic fluorophores were designed based on molecular mechanics. They contain biaryl linkers to impart rigidity preventing intramolecular folding between a conjugated biomolecule and fluorophore. All probes have absorption and emission maxima within 20 nm from Texas Red, as predicted by TDDFT calculations and validated experimentally.

NEAR-INFRARED NERVE-SPARING FLUOROPHORES

Provided are far red to near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.

Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization

The signal transducer and activator of transcription 3 (STAT3) protein is a master regulator of most key hallmarks and enablers of cancer, including cell proliferation and the response to DNA damage. G-Quadruplex (G4) structures are four-stranded noncanonical DNA structures enriched at telomeres and oncogenes' promoters. In cancer cells, stabilization of G4 DNAs leads to replication stress and DNA damage accumulation and is therefore considered a promising target for oncotherapy. Here, we designed and synthesized novel quinazoline-based compounds that simultaneously and selectively affect these two well-recognized cancer targets, G4 DNA structures and the STAT3 protein. Using a combination of in vitro assays, NMR, and molecular dynamics simulations, we show that these small, uncharged compounds not only bind to the STAT3 protein but also stabilize G4 structures. In human cultured cells, the compounds inhibit phosphorylation-dependent activation of STAT3 without affecting the antiapoptotic factor STAT1 and cause increased formation of G4 structures, as revealed by the use of a G4 DNA-specific antibody. As a result, treated cells show slower DNA replication, DNA damage checkpoint activation, and an increased apoptotic rate. Importantly, cancer cells are more sensitive to these molecules compared to noncancerous cell lines. This is the first report of a promising class of compounds that not only targets the DNA damage cancer response machinery but also simultaneously inhibits the STAT3-induced cancer cell proliferation, demonstrating a novel approach in cancer therapy.

MADRASIN-DERIVATIVE COMPOUNDS, COMPOSITION AND USES THEREOF FOR TREATING CANCER

The present invention relates to the fields of medicine and in particular cancer treatment. The invention more specifically relates to new compounds which are typically for use as a medicament. In particular, the invention relates to the use of these new compounds for increasing the presentation, typically the production and presentation, of Pioneer Translation Products (PTPs)-derived antigens by cells, in particular cancer cells, or changing the immunopeptidome, in a subject, and inducing or stimulating an immune response in the subject. The present disclosure also relates to uses of such compounds, in particular to prepare a pharmaceutical composition and/or to allow or improve the efficiency of a therapy in a subject in need thereof. The invention also discloses methods for treating a disease, in particular cancer, for preventing or treating cancer metastasis and/or cancer recurrence, in a subject. The present invention in addition provides kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.

COMPOUNDS TARGETING DUAL G-QUADRUPLEX DNA AND STAT3

The present invention relates to novel quinazoline compounds having the formula (I) or (II): (I) (II). The compounds are active both as stabilizers of G-quadruplex DNA structures and as inhibitors of STAT3 phosphorylation. The disclosed compounds are useful in medical treatment, such as the treatment of cancer.

Fluorescence Compounds and Preparation Method Therof

An object of the present invention is to provide a fluorescent compound which is excellent in fluorescence intensity, relative quantum efficiency, and a labeling ratio, thereby being able to be used as a contrast agent composition, and a labeling method using the same. The fluorescent compound according to the present invention is superior in terms of fluorescence intensity, relative quantum efficiency, and the labeling ratio, thereby being able to be effectively used for labeling and dyeing a target material. In addition, the fluorescent compound has excellent optical stability, thereby exhibiting stable fluorescence even for a long time of dyeing, and since the fluorescent compound has excellent fluorescence intensity without accumulation during administration to the body, it is possible to easily perform dyeing and in-vivo imaging even when a small amount of a dye is used compared to conventional dyes, thereby being economically available.(AA) Compound 1-3 (0.013 andmu;M)COPYRIGHT KIPO 2019

DIARYLETHER-BASED FLUOROGENIC PROBES FOR DETECTION OF HYPOCHLOROUS ACID OR HYDROXYL RADICAL

Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening hypochlorous acid or hydroxyl radical. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining hypochlorous acid or hydroxyl radical in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of hypochlorous acid or hydroxyl radical in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening hypochlorous acid or hydroxyl radical or compounds that can increase or decrease the level of hypochlorous acid or hydroxyl radical in chemical and biological samples.