181059-54-1Relevant articles and documents
Synthesis of enantiomerically pure pyrrolidinones as endothelin receptor antagonists
Bhagwat, Shripad S.,Gude, Candido,Chan, Kenneth
, p. 4627 - 4630 (1996)
Enantiomerically pure pyrrolidinones were synthesized as endothelin receptor antagonists. A [2 + 2] cycloaddition of an imine and an enantiomerically pure acid chloride gave two diastereomeric β-lactams which were separated and rearranged to give the enantiomerically pure pyrrolidinones which could be reduced to give the corresponding pyrrolidines.