181222-34-4Relevant academic research and scientific papers
Synthesis and Studies of Potential Inhibitors of CD73 Based on a Triazole Scaffold
Braka, Abdenour,Chaloin, Laurent,Cros-Perrial, Emeline,Grosjean, Félix,Jordheim, Lars Petter,Mathé, Christophe,Peyrottes, Suzanne,Uttaro, Jean-Pierre
, (2021/12/14)
The ecto-5′-nucleotidase CD73 is involved in the production of immunosuppressive adenosine in the tumoral microenvironment and recently became a validated target in immuno-oncology. To avoid formation of CD73-produced adenosine, several series of potential inhibitors of the target enzyme based on a triazole scaffold were synthetized and evaluated on recombinant purified hCD73 and in cell-based assays.
Hypervalent iodine(III)-induced intramolecular cyclization reaction of substituted phenol ethers with an alkyl azido side-chain: A novel and efficient synthesis of quinone imine derivatives
Kita, Yasuyuki,Egi, Masahiro,Ohtsubo, Makoto,Saiki, Toyokazu,Okajima, Akiko,Takada, Takeshi,Tohma, Hirofumi
, p. 241 - 245 (2007/10/03)
Novel and efficient syntheses of quinone imine ketals (2aj) and quinone imines (4ah) from substituted phenol ethers (1ak) bearing an alkyl azido side-chain using the combination of hypervalent iodine(III) reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA) and trimethylsilyl trifluoromethanesulfonate (TMSOTf), have been developed.
