53560-28-4

Upstream product

• 53560-26-2 3-(3,4,5-trimethoxyphenyl)propan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 25173-72-2 3-(3,4,5-trimethoxyphenyl)propanoic acid 

Downstream Products

• 181222-34-4 5-(3-azidopropyl)-1,2,3-trimethoxybenzene 
• 1425513-11-6 1-(3-(3,4,5-trimethoxyphenyl)propyl)-3,10-diphenyldiimidazo[1,2-a:2′,1′-c]quinoxalinium p-toluenesulfonate 

Relevant academic research and scientific papers

Synthesis and Studies of Potential Inhibitors of CD73 Based on a Triazole Scaffold

The ecto-5′-nucleotidase CD73 is involved in the production of immunosuppressive adenosine in the tumoral microenvironment and recently became a validated target in immuno-oncology. To avoid formation of CD73-produced adenosine, several series of potential inhibitors of the target enzyme based on a triazole scaffold were synthetized and evaluated on recombinant purified hCD73 and in cell-based assays.