181271-60-3Relevant academic research and scientific papers
Synthesis of 8-substituted-2-carboxy-4-(4-fluorophenyl)-2,3-dihydro-1,5-benzothiazepines
Upreti, Mani,Pant, Seema,Dandia, Anshu,Pant, Umesh C.
, p. 165 - 171 (1996)
Syntheses of six 8-substituted-2-carboxy-4-(4-fluorophenyl)-2,3-dihydro-1,5-benzothiazepines having as the substituent fluoro, chloro, bromo, alkyl-methyl, alkoxyl-methoxyl and ethoxyl have been achieved by the reaction of 5-substituted-2-aminobenzenethiols with β-(p-fluorobenzoyl)acrylic acid in ethanol saturated with hydrogen chloride gas. The products were tested for purity by TLC. Microestimation of nitrogen, IR and 1H NMR & mass spectral studies have been used for the assignment of structures to the title compounds.
Efficient microwave enhanced solvent-free synthesis of potent antifungal agents: Fluorinated benzothiazepine fused β-lactam derivatives
Dandia, Anshu,Singh, Ruby,Khaturia, Sarita
, p. 524 - 529 (2007/12/25)
A microwave enhanced, facile cycloaddition has been developed for the synthesis of fluorine containing azeto[2,1-d][1,5]benzothiazepine derivatives (Va-m) on the surface of potassium carbonate (K2CO3). Microwave enhanced solvent-free improved synthesis of required 1,5-benzothiazepines is also developed using montmorillonite clay. The synthesized compounds have been screened 'in vitro' for antifungal activity against Rhizoctonia solani, Fusarium oxysporum and Collectotrichum capsici. Most of the compounds have shown good activity against these pathogens.
