Synthesis of 8-substituted-2-carboxy-4-(4-fluorophenyl)-2,3-dihydro-1,5-benzothiazepines

Article abstract of DOI:10.1080/10426509608046387

Syntheses of six 8-substituted-2-carboxy-4-(4-fluorophenyl)-2,3-dihydro-1,5-benzothiazepines having as the substituent fluoro, chloro, bromo, alkyl-methyl, alkoxyl-methoxyl and ethoxyl have been achieved by the reaction of 5-substituted-2-aminobenzenethiols with β-(p-fluorobenzoyl)acrylic acid in ethanol saturated with hydrogen chloride gas. The products were tested for purity by TLC. Microestimation of nitrogen, IR and ¹H NMR & mass spectral studies have been used for the assignment of structures to the title compounds.

Full text of DOI:10.1080/10426509608046387

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Phosphorus, Sulfur, and Silicon and the
Related Elements
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SYNTHESIS OF 8-SUBSTITUTED-2-
CARBOXY-4-(4-FLUOROPHENYL)-2,3-
DIHYDRO-1,5-BENZOTHIAZEPINES
Mani Upreti a , Seema Pant a , Anshu Dandia a & Umesh C. Pant a
a Department of Chemistry , University of Rajasthan , Jaipur,
302004, India
Published online: 04 Oct 2006.
To cite this article: Mani Upreti , Seema Pant , Anshu Dandia & Umesh C. Pant (1996) SYNTHESIS OF
8-SUBSTITUTED-2-CARBOXY-4-(4-FLUOROPHENYL)-2,3-DIHYDRO-1,5-BENZOTHIAZEPINES, Phosphorus,
Sulfur, and Silicon and the Related Elements, 113:1-4, 165-171, DOI: 10.1080/10426509608046387
To link to this article: http://dx.doi.org/10.1080/10426509608046387
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