181364-80-7

Usage

Type of compound

Organic compound

Derivative of

N,N-diethylacetamide

Common uses

Solvent, anesthetic

Unique property

Presence of a bromophenyl group

Applications

Pharmaceuticals, synthesis of organic compounds, intermediate in manufacturing of other chemicals

Toxicity

Moderately toxic

Hazards

Skin and eye irritant

Safety measures

Handle with care and proper safety measures in place

Upstream product

• 37859-24-8 2-(4-bromophenyl)acetyl chloride 
• 109-89-7 diethylamine 
• 934-94-1 1-bromo-4-bromoethynyl-benzene 
• 121-44-8 triethylamine 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 

Downstream Products

• 93653-26-0 (4-bromo-phenyl)-[2]pyridyl-acetic acid diethylamide 
• 27200-79-9 p-bromophenylacetaldehyde 
• 6186-23-8 1-(4-bromophenyl)propan-2-ol 

Relevant academic research and scientific papers

Direct amidation of carboxylic acids with tertiary amines: Amide formation over copper catalysts through C-N bond cleavage

A copper-catalyzed system for the amidation of carboxylic acids with tert-amines through C-N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction. Copyright

Practical synthesis of amides from alkynyl bromides, amines, and water

A general and efficient method for the synthesis of a wide range of amides is described here. The reactions were conducted under convenient conditions and provided secondary and tertiary amides in moderate to excellent yields. A variety of amines and substituted alkynyl bromides were used to investigate the scope of the reactions.