6186-23-8

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Bromophenyl)-2-propanol is used as an intermediate in the synthesis of 4-Bromo Amphetamine Hydrochloride (B679600), a 4-brominated analogue of the central nervous system (CNS) stimulant Amphetamine (A634248). This intermediate plays a crucial role in the production of medications that target the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity, among other conditions.
Additionally, 1-(4-Bromophenyl)-2-propanol may be utilized in the development of other pharmaceutical compounds, given its unique structural features and reactivity. Its applications in the pharmaceutical industry are primarily due to its ability to act as a building block for the synthesis of various drugs with potential therapeutic benefits.

Upstream product

• 27200-79-9 p-bromophenylacetaldehyde 
• 75-16-1 methylmagnesium bromide 
• 6186-22-7 4-bromophenyl acetone 
• 4489-23-0 1-bromo-4-(prop-1-en-1-yl)benzene 
• 98-80-6 phenylboronic acid 
• 56856-82-7 2-(4'-bromophenyl)-3-methyloxirane 
• 181364-80-7 2-(4-bromophenyl)-N,N-diethylacetamide 

Relevant academic research and scientific papers

A General Regioselective Synthesis of Alcohols by Cobalt-Catalyzed Hydrogenation of Epoxides

A straightforward methodology for the synthesis of anti-Markovnikov-type alcohols is presented. By using a specific cobalt triphos complex in the presence of Zn(OTf)2 as an additive, the hydrogenation of epoxides proceeds with high yields and selectivities. The described protocol shows a broad substrate scope, including multi-substituted internal and terminal epoxides, as well as a good functional-group tolerance. Various natural-product derivatives, including steroids, terpenoids, and sesquiterpenoids, gave access to the corresponding alcohols in moderate-to-excellent yields.

ANTIMICROBIAL COMPOUNDS AND METHODS

The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.

ANTIMICROBIAL COMPOUNDS AND METHODS

The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.

Hetero-Bimetallic Complexes Based on an Anthyridine Ligand Preparation and Catalytic Activity

Complexation of anthyridine-based ligand L with [(η6-cymene)RuCl2]2, [Cp*RhCl2]2, and [Cp*IrCl2]2 yielded a mononuclear complex: [(N,N-L)Ru(η6-cymene)Cl]Cl (1), [(N,N-L)Rh(Cp*)Cl]Cl (2), and [(N,N-L)Ir(Cp*)Cl]Cl (3), respectively [L = 5-phenyl-2,8-di-2-pyridinylanthyridine]. Upon treatment with (CH3CN)PdCl2, complexes 1-3 underwent o-metalation to yield heterobimetallic complexes Ru-Pd, Rh-Pd, and Ir-Pd, respectively. Complexes were all characterized by spectroscopic method, and some are further confirmed by X-ray crystallography. Complex Ru-Pd exhibits catalytic activities for the tandem reactions of Suzuki-Miyaura coupling/transfer hydrogenation of p-bromoacetophenone with phenylboronic acid in isopropanol, whereas Ir-Pd shows a moderate activity. However, complex Rh-Pd does not behave the same way. Furthermore, catalytic activity of these heterobimetallic complexes toward debromination/transfer hydrogenation of p-bromoacetophenonewas also investigated. The catalytic pathways of these processes were studied and discussed. This study reveals the base used in the reactions plays an important role in the reaction pathway.

LILY OF THE VALLEY ODORANT

The present invention concerns the use as perfuming ingredient of a compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof, and wherein X represents a CHO group when R1 represents a C1-2 alkyl group

Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins

Considering that stoichiometric borane and oxidant are required in the classical alkene anti-Markovnikov hydration process, it remains appealing to achieve the transformation in a catalytic protocol. Herein, a visible-light-mediated anti-Markovnikov addition of water to alkenes by using an organic photoredox catalyst in conjunction with a redox-active hydrogen atom donor was developed, which avoided the need for a transition-metal catalyst, stoichiometric borane, as well as oxidant. Both terminal and internal olefins are readily accommodated in this transformation to obtain corresponding primary and secondary alcohols in good yields with single regioselectivity. This procedure can be scaled up to gram scale with a 230 turnover number based on photocatalyst.

Ruthenium Catalyzed Selective Hydroboration of Carbonyl Compounds

Using the [Ru(p-cymene)Cl2]2 (1) complex, catalytic hydroboration of aldehydes and ketones with pinacolborane under neat and mild conditions is reported. At rt, chemoselective hydroboration of aldehydes over the ketones is also attained. Mechanistic studies confirmed the immediate formation of monohydride bridged dinuclear complex [{(μ6-p-cymene)RuCl}2(μ-H-μ-Cl)] (1b) from the reaction of 1 with pinacolborane, which catalyzed the highly efficient hydroboration reactions. The catalytic cycle containing mononuclear Ru-H species and intramolecular 1,3-hydride transfer is postulated.

Ein allgemein einsetzbares, mildes Eintopfverfahren zur Umwandlung von Amiden in Aldehyde

Keywords: Aldehyde; Enamine; Hydrosilylierungen; Titanverbindungen