181426-99-3

Upstream product

• 100-42-5 styrene 
• 181427-31-6 1-Amino-6,8-difluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 100276-63-9 ethyl 1-amino-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate 
• 79660-46-1 ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 109-01-3 1-methyl-piperazine 

Relevant academic research and scientific papers

Synthesis of N-(1-aziridinyl)-6-fluoro-l,4-dihydro-4-oxoquinoline-3-carboxylic acids

A series of N-(1-aziridinyl)quinoline-3-carboxylic acid derivatives (e.g. 11a-f, 20a-g, 21a-d) have been synthesized by insertion reaction of nitrenes (e.g. ethyl 7-chloro-6-fluoro-1-nitreno-1,4-dihydro-4-oxoquinoline-3 -carboxylate (9)) into double bond of different olefins (e.g. styrene (10a), see Schemes 2 and 4). The nitrenes were formed in situ by oxidation of N-aminoquinolin-4(1H)-one derivatives (8, 18a,b) using Pb(OAc)4 as oxidizing agent.

Synthesis and biological evaluation of N-(1-aziridino)-6-fluoro- quinolone-3-carboxylic acids

New racemic N-(1-aziridino)-6-flouro-7-(4-methylpiperazin-1-yl)-4(1H)- quinolone-3-carboxylic acids (9a-i) were synthesized and their antibacterial activities were tested against Gram-positive and Gram-negative micro- organisms. According to the MIC, all compounds studied are less active than Ciprofloxacin; two of them (9a,b) have similar activity as Nalidixic acid (1).