Welcome to LookChem.com Sign In|Join Free

CAS

  • or

181473-92-7

Post Buying Request

181473-92-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

181473-92-7 Usage

General Description

(5-chloro-2-methoxyphenyl)methanamine is a chemical compound that belongs to the class of organic compounds known as anilines. It is a derivative of aniline, which is a basic aromatic amine. (5-chloro-2-methoxyphenyl)methanamine is identified by its molecular structure, which consists of a chloro-substituted phenyl group attached to a methanamine moiety through a methoxy linkage. The presence of a chlorine atom and a methoxy group makes this compound a useful intermediate in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. Additionally, it can be used as a building block for the creation of dyes, pigments, and other fine chemicals. The unique properties of (5-chloro-2-methoxyphenyl)methanamine make it valuable for a wide range of industrial applications.

Check Digit Verification of cas no

The CAS Registry Mumber 181473-92-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,4,7 and 3 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 181473-92:
(8*1)+(7*8)+(6*1)+(5*4)+(4*7)+(3*3)+(2*9)+(1*2)=147
147 % 10 = 7
So 181473-92-7 is a valid CAS Registry Number.

181473-92-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (5-Chloro-2-methoxyphenyl)methanamine

1.2 Other means of identification

Product number -
Other names Benzenemethanamine,5-chloro-2-methoxy

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:181473-92-7 SDS

181473-92-7Relevant articles and documents

MODULATORS OF TMEM16A FOR TREATING RESPIRATORY DISEASE

-

Page/Page column 55; 56, (2020/12/30)

Compounds of general formula (I), which are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A. wherein A is defined as Formula.

N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: Screening, synthesis of simplified derivatives, and structure-activity relationship analysis

Goffin, Eric,Lamoral-Theys, Delphine,Tajeddine, Nicolas,De Tullio, Pascal,Mondin, Ludivine,Lefranc, Florence,Gailly, Philippe,Rogister, Bernard,Kiss, Robert,Pirotte, Bernard

experimental part, p. 834 - 844 (2012/09/11)

A series of chroman derivatives previously reported as potassium channel openers, as well as some newly synthesized simplified structures, were examined for their in vitro effects on the growth of three human high-grade glioma cell lines: U373, T98G, and Hs683. Significant in vitro growth inhibitory activity was observed with 2,2-dimethylchroman-type nitro-substituted phenylthioureas, such as compounds 4o and 4p. Interestingly, most tested phenylureas were found to be slightly less active, but more cell selective (normal versus tumor glial cells, such as 3d, 3e, and 3g), thus less toxic, than the corresponding phenylthioureas. No significant differences were observed in terms of chroman-derivative-induced growth inhibitory effects between glioma cells sensitive to pro-apoptotic stimuli (Hs683 glioma cells) and glioma cells associated with various levels of resistance to pro-apoptotic stimuli (U373 and T98G glioma cells), a feature that suggests non-apoptotic-mediated growth inhibition. Flow cytometry analyses confirmed the absence of pro-apoptotic effects for phenylthioureas and phenylureas when analyzed in U373 glioma cells and demonstrated U373 cell cycle arrest in the G0/G1 phase. Computer-assisted phase-contrast videomicroscopy revealed that 3d and 3g displayed cytostatic effects, while 3e displayed cytotoxic ones. As a result, this work identified phenylurea-type 2,2-dimethylchromans as a new class of antitumor agents to be further explored for an innovative therapeutic approach for high-grade glioma and/or for a possible new mechanism of action.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 181473-92-7