181486-36-2

Upstream product

• 181486-34-0 3,5-dioxo-1-methylcyclohexane carboxylic acid methyl ester 
• 78640-30-9 methyl 3,5-dimethoxy-1-methylcyclohexa-2,5-diene-1-carboxylate 
• 181486-35-1 3-Acetoxy-1-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester 

Downstream Products

• 181486-37-3 4-acetyl-3,5-dioxo-1-methylcyclohexane carboxylic acid 
• 181486-39-5 (S)-2-{1-[4-((S)-1-Methoxycarbonyl-2-phenyl-ethylcarbamoyl)-4-methyl-2,6-dioxo-cyclohexylidene]-ethylamino}-3-phenyl-propionic acid methyl ester 

Relevant academic research and scientific papers

A new linker for primary amines applicable to combinatorial approaches

We describe a new linker molecule (ADCC-linker) for the attachment of primary amines to solid support. The linker is stable towards acidic conditions (eg. TFA) basic conditions (eg. piperidine, DBU) as well as towards uronium type coupling reagents. The amine can be quantitatively released from the support using a 2% hydrazine in DMF solution.