181519-32-4

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 3-amino-3-(4-fluorophenyl)propanoate HCl is used as a precursor or intermediate for the synthesis of various medications, contributing to the development of new therapeutic agents.
Used in Organic Chemistry:
Methyl 3-amino-3-(4-fluorophenyl)propanoate HCl is used as a chemical intermediate in organic chemistry, facilitating the synthesis of complex organic compounds and aiding in research and development of novel chemical entities.
Used in Chemical Research:
Methyl 3-amino-3-(4-fluorophenyl)propanoate HCl is employed in chemical research to explore its properties, reactivity, and potential applications in the synthesis of pharmaceuticals and other organic compounds.

Upstream product

• 67-56-1 methanol 
• 325-89-3 3-amino-3-(4-fluorophenyl)propanoic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 225517-06-6 3-(N-tert-butyloxycarbonyl)amino-3-(4-fluorophenyl)propionic acid, methyl ester 

Downstream Products

• 1417905-73-7 C₁₉H₁₈FNO₆ 
• 1417905-74-8 C₁₇H₁₄FNO₆ 
• 1417905-75-9 C₁₈H₁₆FNO₆ 
• 1430093-77-8 C₃₃H₄₁N₅O₂ 
• 1430093-76-7 C₃₈H₄₉N₅O₄ 
• 1430093-75-6 C₃₈H₄₈N₄O₅ 
• 1430093-74-5 C₃₉H₅₀N₄O₅ 
• 1430093-73-4 C₂₂H₃₆N₄O₄ 
• 1430093-72-3 C₂₂H₃₄N₄O₆ 
• 1430093-64-3 C₁₅H₁₉FN₂O₆ 
• 1430093-71-2 C₁₀H₁₁FN₂O₄ 
• 1269634-21-0 methyl 3-benzamido-3-(4-fluorophenyl)propanoate 
• 1647-94-5 3-benzamido-3-(4-fluorophenyl)propanoic acid 
• 1257211-79-2 (R)-1-[3-benzamido-3-(4-fluorophenyl)propanamido]-3-methylbutylboronic acid 

Relevant academic research and scientific papers

From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies

A concise synthesis of benzimidazole-substituted β-amido-amide LLW62 is presented. The original synthesis of compounds related to LLW62 was developed on Rink resin as part of a "one-bead, one-compound" combinatorial approach for on-bead screening purposes. The current synthesis is carried out in solution and is amenable to scale-up for follow-up studies on LLW62 and investigations of related structures. The key step involves the use of a β-amino acid-forming three-component reaction (3CR), the scope of which defines its role in the synthetic strategy.

Stereoselective chemoenzymatic preparation of β-amino esters: Molecular modelling considerations in lipase-mediated processes and application to the synthesis of (S)-dapoxetine

A wide range of optically active 3-amino-3-arylpropanoic acid derivatives have been prepared by means of a stereoselective chemoenzymatic route. The key step is the kinetic resolution of the corresponding β-amino esters. Although the enzymatic acylations of the amino group with ethyl methoxyacetate showed synthetically useful enantioselectivities, the hydrolyses of the ester group catalyzed by lipase from Pseudomonas cepacia have been identified as the optimal processes concerning both activity and enantioselectivity. The enantiopreference of this lipase in these reactions has been explained, at the molecular level, by using a fragment-based approach in which the most favoured binding site for a phenyl ring and the most stable conformation of the 3-aminopropanoate core nicely match the (S)-configuration of the major products. The conversion and enantioselectivity values of the enzymatic reactions have been compared in order to understand the influence of the different substitution patterns present in the phenyl ring. This chemoenzymatic route has been successfully applied to the preparation of a valuable intermediate in the synthesis of (S)-dapoxetine, which has been chemically synthesised in excellent optical purity.

Synthesis, in vitro and in vivo biological evaluation, and comprehensive understanding of structure-activity relationships of dipeptidyl boronic acid proteasome inhibitors constructed from β-amino acids

An extensive structure-activity relationship (SAR) study of 72 dipeptidyl boronic acid proteasome inhibitors constructed fromβ -amino acids is reported. SAR analysis revealed that bicyclic groups at the R1 position, 3-F substituents at the Rsu

Substituted β-alanine derivatives as cell adhesion inhibitors

β-Alanine derivatives of Formula I are antagonists of VLA-4 and/or α4β7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.