Welcome to LookChem.com Sign In|Join Free

CAS

  • or

2234-14-2

Post Buying Request

2234-14-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

2234-14-2 Usage

Chemical Properties

white fine crystalline powder

Uses

2',4',6'-Triisopropylacetophenone is used as a pharmaceutical intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 2234-14-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,3 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2234-14:
(6*2)+(5*2)+(4*3)+(3*4)+(2*1)+(1*4)=52
52 % 10 = 2
So 2234-14-2 is a valid CAS Registry Number.

2234-14-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A13693)  2',4',6'-Triisopropylacetophenone, 98+%   

  • 2234-14-2

  • 5g

  • 282.0CNY

  • Detail
  • Alfa Aesar

  • (A13693)  2',4',6'-Triisopropylacetophenone, 98+%   

  • 2234-14-2

  • 25g

  • 659.0CNY

  • Detail
  • Alfa Aesar

  • (A13693)  2',4',6'-Triisopropylacetophenone, 98+%   

  • 2234-14-2

  • 100g

  • 2269.0CNY

  • Detail
  • Alfa Aesar

  • (A13693)  2',4',6'-Triisopropylacetophenone, 98+%   

  • 2234-14-2

  • 500g

  • 9643.0CNY

  • Detail

2234-14-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[2,4,6-tri(propan-2-yl)phenyl]ethanone

1.2 Other means of identification

Product number -
Other names 2,4,6-tri-i-propylacetophenone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2234-14-2 SDS

2234-14-2Relevant articles and documents

Steric Demand and Rate-determining Step for Photoenolization of Di-ortho-substituted Acetophenone Derivatives

Das, Anushree,Thomas, Suma S.,Garofoli, August A.,Chavez, Kevin A.,Krause, Jeanette A.,Bohne, Cornelia,Gudmundsdottir, Anna D.

, p. 154 - 162 (2019)

Laser flash photolysis of ketone 1 in argon-saturated methanol yields triplet biradical 1BR (τ = 63 ns) that intersystem crosses to form photoenols Z-1P (λmax = 350 nm, τ ~ 10 μs) and E-1P (λmax = 350 nm, τ > 6 ms). The activation barrier for Z-1P re-forming ketone 1 through a 1,5-H shift was determined as 7.7 ± 0.3 kcal mol?1. In contrast, for ketone 2, which has a less sterically hindered carbonyl moiety, laser flash photolysis in argon-saturated methanol revealed the formation of biradical 2BR (λmax = 330 nm, τ ~ 303 ns) that intersystem crosses to form photoenol E-2P (λmax = 350 nm, τ > 42 μs), but photoenol Z-2P was not detected. However, in more viscous basic H-bond acceptor (BHA) solvent, such as hexamethylphosphoramide, triplet 2BR intersystem crosses to form both Z-2P (λmax = 370 nm, τ ~ 1.5 μs) and E-2P. Thus, laser flash photolysis of ketone 2 in methanol reveals that intersystem crossing from 2BR to form Z-2P is slower than the 1,5-H shift of Z-2P, whereas in viscous BHA solvents, the 1,5-H shift becomes slower than the intersystem crossing from 2BR to Z-2P. Density functional theory and coupled cluster calculations were performed to support the reaction mechanisms for photoenolization of ketones 1 and 2.

Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains

Cvijeti?, Ilija N.,Verbi?, Tatjana ?.,Ernesto de Resende, Pedro,Stapleton, Paul,Gibbons, Simon,Jurani?, Ivan O.,Drakuli?, Branko J.,Zloh, Mire

, p. 1474 - 1488 (2017/11/17)

Antimicrobial resistance (AMR) is a major health problem worldwide, because of ability of bacteria, fungi and viruses to evade known therapeutic agents used in treatment of infections. Aryldiketo acids (ADK) have shown antimicrobial activity against several resistant strains including Gram-positive Staphylococcus aureus bacteria. Our previous studies revealed that ADK analogues having bulky alkyl group in ortho position on a phenyl ring have up to ten times better activity than norfloxacin against the same strains. Rational modifications of analogues by introduction of hydrophobic substituents on the aromatic ring has led to more than tenfold increase in antibacterial activity against multidrug resistant Gram positive strains. To elucidate a potential mechanism of action for this potentially novel class of antimicrobials, several bacterial enzymes were identified as putative targets according to literature data and pharmacophoric similarity searches for potent ADK analogues. Among the seven bacterial targets chosen, the strongest favorable binding interactions were observed between most active analogue and S. aureus dehydrosqualene synthase and DNA gyrase. Furthermore, the docking results in combination with literature data suggest that these novel molecules could also target several other bacterial enzymes, including prenyl-transferases and methionine aminopeptidase. These results and our statistically significant 3D QSAR model could be used to guide the further design of more potent derivatives as well as in virtual screening for novel antibacterial agents.

Observation of 1,3-diketones formation in the reaction of bulky acyl chlorides with methyllithium

Zhang, Jian,Yang, Nianfa,Yang, Liwen

, p. 6415 - 6423 (2012/09/08)

The formation of 1,3-diketones was observed in the reactions of bulky acyl chlorides with methyllithium. The reaction products depend on the steric hindrance around the carbonyl group of the acyl chloride and the electronic effect of the group(s) linked to the carbonyl. When the steric hindrance around the carbonyl group of the acyl chloride is big enough, the 1,3-diketone is the only product. In the case of the moderate hindrance around the carbonyl group of the acyl chloride, a moderate yield of 1,3-diketone is obtained and some tertiary alcohol is generated. When there is no steric hindrance around the carbonyl group of the acyl chloride, the tertiary alcohol is the only product. When the steric hindrance around the carbonyl group is moderate and an electron-donating group is connected to the carbonyl of the acyl chloride, all three products-ketone, 1,3-diketone and tertiary alcohol-can be isolated from the reaction mixture after long reaction times.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 2234-14-2