18159-17-6Relevant academic research and scientific papers
Design and synthesis of non-peptide mimetics mapping the immunodominant myelin basic protein (MBP83-96) epitope to function as T-cell receptor antagonists
Yannakakis, Mary-Patricia,Simal, Carmen,Tzoupis, Haralambos,Rodi, Maria,Dargahi, Narges,Prakash, Monica,Mouzaki, Athanasia,Platts, James A.,Apostolopoulos, Vasso,Tselios, Theodore V.
, (2017)
Encephalitogenic T cells are heavily implicated in the pathogenesis of multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system. Their stimulation is triggered by the formation of a trimolecular complex between the human
Br?nsted Acid Catalyzed Cyclization of Aminodiazoesters with Aldehydes to 3a'Carboxylatea'Na'Heterocycles
Jiao, Yang,Chen, Anrong,Yu, Bangkui,Huang, Hanmin
supporting information, p. 6031 - 6034 (2020/09/01)
A Br?nsted acid catalyzed cyclization of aminodiazoesters with aldehydes is described. This reaction features broad substrate generality and functional group compatibility, affording a wide range of 5a'7-membered 3-carboxylate-N-heterocycles containing different functional groups. The title products are able to be further elaborated through simple functional group transformations to produce synthetically useful N-heterocycles.
Synthesis of novel furo-, thieno-, and pyrroloazepines
Villarreal, Carlos,Martinez, Roberto
experimental part, p. 3346 - 3352 (2010/11/17)
The synthesis of novel furo-, thieno-, and pyrroloazepine compounds, using the oxidative radical alkylation of three five-membered heterocyclic 3-acetic acid derivatives, is described. The bicyclic systems were obtained, via a small number of steps, directly from commercially available materials. Georg Thieme Verlag Stuttgart New York.
