181632-25-7 Usage
Uses
Used in Pharmaceutical Industry:
6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride is used as a pharmaceutical compound for its potential therapeutic effects. Its specific application reason is due to its unique chemical structure, which may allow it to interact with various biological targets and exhibit desired pharmacological properties.
Used in Chemical Research:
In the field of chemical research, 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride can be used as a research tool to study the interactions between different molecules and to develop new synthetic methods or understand the reactivity of similar compounds. The application reason is its complex structure, which may provide insights into the design and synthesis of other related compounds with potential applications.
Chemical Properties:
The chemical properties of 6-Chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline hydrate dihydrochloride, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide hydrate dihydrochloride are not explicitly provided in the materials. However, given its complex structure, it is likely to exhibit a range of chemical properties that can be useful in various applications, such as its reactivity, solubility, and stability under different conditions.
Biological Activity
5-HT 2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT 2A and 5-HT 2B receptors respectively. Also displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors. Brain penetrant; exerts anxiolytic-like activity.
Biochem/physiol Actions
SB 242084 is a potent and selective antagonist of 5-HT2C receptor. It increases the basal activity of dopaminergic neurons and affects the behavioral responses mediated by 5-HT2C such as mesolimbic neuron activity and food intake.3,4,5
Check Digit Verification of cas no
The CAS Registry Mumber 181632-25-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,6,3 and 2 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 181632-25:
(8*1)+(7*8)+(6*1)+(5*6)+(4*3)+(3*2)+(2*2)+(1*5)=127
127 % 10 = 7
So 181632-25-7 is a valid CAS Registry Number.
181632-25-7Relevant academic research and scientific papers
Preparation method of indoline compound
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, (2017/08/25)
The invention discloses a preparation of indoline compound expressed by the following general formula 1; the method successfully passes through for step reactions by applying iodine monochloride, acetenyl trimethyl silane and other reaction reagents, and obtains 6-chlorine-5-methyl indoline. Relative to the prior art, the synthetic method of the indoline derivative reduces the reaction step while improves the reaction yield. Moreover, the reaction condition is gentle, and easy to control; the method is good for large-scale industrial production.
Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: Identification of 5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent
Bromidge, Steven M.,Dabbs, Steven,Davies, David T.,Davies, Susannah,Duckworth, D. Malcolm,Forbes, Ian T.,Gaster, Laramie M.,Ham, Peter,Jones, Graham E.,King, Frank D.,Mulholland, Keith R.,Saunders, Damian V.,Wyman, Paul A.,Blaney, Frank E.,Clarke, Stephen E.,Blackburn, Thomas P.,Holland, Vicky,Kennett, Guy A.,Lightowler, Sean,Middlemiss, Derek N.,Trail, Brenda,Riley, Graham J.,Wood, Martyn D.
, p. 1123 - 1134 (2007/10/03)
The evolution, synthesis, and biological activity of a novel series of 5-HT(2C) receptor inverse agonists are reported. Biarylcarbamoylindolines have been identified with excellent 5-HT(2C) affinity and selectivity over 5- HT(2A) receptors. In addition, (pyridyloxypyridyl)carbamoylindolines have been discovered with additional selectivity over the closely related 5-HT(2B) receptor. Compounds from this series are inverse agonists at the human cloned 5-HT(2C) receptor, completely abolishing basal activity in a functional assay. The new series have reduced P450 inhibitory liability compared to a previously described series of 1-(3-pyridylcarbamoyl)indolines (Bromidge et al. J. Med. Chem. 1998, 41, 1598) from which they evolved. Compounds from this series showed excellent oral activity in a rat mCPP hypolocomotion model and in animal models of anxiety. On the basis of their favorable biological profile, 32 (SB-228357) and 40 (SB-243213) have been selected for further evaluation to determine their therapeutic potential for the treatment of CNS disorders such as depression and anxiety.
