1121-25-1

Basic information

• Product Name: 3-Hydroxy-2-methylpyridine
• Synonyms: 3-HYDROXY-2-METHYLPYRIDINE;3-HYDROXY-2-PICOLINE;2-METHYL-3-PYRIDINOL;2-Methyl-3-hydroxypyridine;3-Pyridinol, 2-methyl-;3-HYDROXY-2-METHYLPYRIDINE 99%;3-HYDROXY-2-METHYLPYRIDINE 2-METHYLPYRIDIN-3-OL;3-HYDROXY-2-METHYLPYRIDINE (3-HYDROXY-2-PICOLINE)
• CAS NO: 1121-25-1
• Molecular Formula: C₆H₇NO
• Molecular Weight: 109.13
• EINECS: 214-327-3
• Product Categories: Pyridine series;Pyridine;pyrdine series;Heterocycles
• Mol File: 1121-25-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 168-169 °C(lit.)
• Boiling Point: 204.59°C (rough estimate)
• Flash Point: 127.4 °C
• Appearance: Beige-brown/Powder
• Density: 1.1143 (rough estimate)
• Vapor Pressure: 0.00147mmHg at 25°C
• Refractive Index: 1.5040 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO, Methanol
• PKA: 10.38±0.10(Predicted)
• BRN: 107937
• CAS DataBase Reference: 3-Hydroxy-2-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-2-methylpyridine(1121-25-1)
• EPA Substance Registry System: 3-Hydroxy-2-methylpyridine(1121-25-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-37/39-36/37/39-36
• WGK Germany: 3
• Hazardous Substances Data: 1121-25-1(Hazardous Substances Data)

Usage

Chemical Properties

beige-brown powder

Uses

Different sources of media describe the Uses of 1121-25-1 differently. You can refer to the following data:
1. 3-Hydroxy-2-methylpyridine is used in the preparation of substituted pyridine and pyrimidine derivatives and their use in treating viral infections.
2. 3-Hydroxy-2-methylpyridine was used in the synthesis of pyrimidine.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 2969, 1949 DOI: 10.1021/ja01177a007

General Description

Vitamin B6 is an active 3-hydroxy-2-methylpyridine derivative.

InChI:InChI=1/C6H7NO/c1-5-6(8)3-2-4-7-5/h2-4,8H,1H3

Upstream product

• 931-19-1 2-methylpyridine N-oxide 
• 108-24-7 acetic anhydride 
• 87440-88-8 2-bromomethyl-3-hydroxypyridine hydrobromide 
• 2168-13-0 2-[(dimethylamino)methyl]pyridin-3-ol 
• 7647-01-0 hydrogenchloride 
• 98552-86-4 1-(2,5-dimethoxy-2,5-dihydro-[2]furyl)-ethylamine 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 7664-41-7 ammonia 
• 67-56-1 methanol 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 1000414-75-4 (2S)-1-benzyl-2-methyl-1,6-dihydropyridin-3(2H)-one 
• 67992-22-7 3-acetoxy-2-acetoxymethyl-pyridine 
• 17682-71-2 2,3-O-isopropylidene-α-L-sorbofuranose 

Downstream Products

• 177557-56-1 2-(3-o-benzylbenzyl-8-(carbomethoxymethyloxy)-2-ethylindolizin-1-yl)glyoxylamide 
• 1027326-10-8 [8-Benzyloxy-3-(3,5-di-tert-butyl-benzyl)-2-ethyl-indolizin-1-yl]-oxo-acetyl chloride 
• 177557-32-3 2-(8-benzyloxy-3-(3,5-di-t-butylbenzyl-2-ethylindolizin-1-yl))glyoxylamide 
• 177557-91-4 2-(8-carbomethoxymethyloxy-2-cyclopentyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide 
• 177557-54-9 2-(8-(carbomethoxymethyloxy)-3-(3,5-di-t-butylbenzyl)-2-ethylindolizin-1-yl)glyoxylamide 
• 313656-68-7 2-(2-Methyl-pyridin-3-yloxy)ethanol 
• 177557-36-7 2-(8-benzyloxy-2-ethyl-3-((3-thiophen-2-yl)thiophen-2-ylmethyl)indolizin-1-yl)glyoxylamide 
• 177557-89-0 2-(3-(Biphenyl-2-ylmethyl)-8-(carbomethoxymethyloxy)-2-isopropylindolizin-1-yl)glyoxylamide 
• 177557-60-7 2-(2-Ethyl-8-(carbomethoxymethyloxy)-3-(o-nitrobenzyl)indolizine-1-yl)glyoxylamide 
• 1197005-35-8 C₂₇H₂₉FN₃O₄P 
• 1027896-76-9 (3-Biphenyl-2-ylmethyl-2-tert-butyl-1-chlorooxalyl-indolizin-8-yloxy)-acetic acid methyl ester 
• 177557-90-3 2-(2-t-butyl-8-carbomethoxymethyloxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylamide 

Relevant articles and documents

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Conversion of 5-hydroxymethylfurfural into 6-(hydroxymethyl)pyridin-3-ol: A pathway for the formation of pyridin-3-ols in honey and model systems

The formation of 6-(hydroxymethyl)pyridin-3-ol by ring expansion of 5-(hydroxymethyl)furfural (HMF) in the presence of ammonia-producing compounds was studied to determine the routes of formation of pyridin-3-ols in foods. 6-(Hydroxymethyl)pyridin-3-ol was produced from HMF in model systems, mostly at neutral pH values, as a function of reaction times and temperature and with an activation energy (Ea) of 74 ± 3 kJ/mol, which was higher than that of HMF disappearance (43 ± 4 kJ/mol). A reaction pathway is proposed, which is general for the formation of pyridin-3-ols from 2-oxofurans. Thus, it explains the conversions of furfural into pyridin-3-ol and of 2-acetylfuran into 2-methylpyridin-3-ol, which were also studied. When honey and sugarcane honey were heated, they produced different pyridin-3-ols, although 6-(hydroxymethyl)pyridin-3-ol was the pyridine-3-ol produced to the highest extent. Obtained results suggest that formation of pyridin-3-ols in foods is unavoidable when 2-oxofurans are submitted to thermal heating and ammonia (or ammonia-producing compounds) is present.

Negishi coupling strategy of a repetitive two-step method for oligoarene synthesis

A novel repetitive two-step method for oligoarene synthesis, based on Negishi cross-coupling of zinciophenoxides or zinciopyridinoxides with aryl triflates and subsequent triflation of the hydroxy group, was developed. Reaction conditions were optimized for the preparation of the arylzinc compounds and the palladium-catalyzed cross-coupling step.

An efficient facile and selective hydroxylation of nitrogen heterocycles

Nitrogen heterocycles have been efficiently hydroxylated under mild and neutral conditions by employing Cupric nitrate/phosphate buffer/30%hydrogen peroxide system. The present method afforded the biologically active and important hydroxy heterocycles. Th