18166-56-8Relevant academic research and scientific papers
Direct NHC-catalysed redox amidation using CO2 for traceless masking of amine nucleophiles
Davidson, Robert W. M.,Fuchter, Matthew J.
, p. 11638 - 11641 (2016/10/04)
The N-heterocyclic carbene (NHC)-catalysed redox amidation reaction is poorly developed and usually requires catalytic co-additives for electron-rich amine nucleophiles. We report a masking strategy (using CO2) that couples release of the free amine nucleophile to catalytic turnover, and in doing so, enables direct catalytic redox amidation of electron-rich amines.
REACTIONS OF ARYLDIAZONIUM TETRAFLUOROBORATES WITH ACRYLAMIDE IN THE PRESENCE OF THIOCYANATES, BROMIDES, AND CHLORIDES OF ALKALI METALS AND AMMONIUM
Grishchuk, B. D.,Gorbovoi, P. M.,Kudrik, E. Ya.,Ganushchak, N. I.
, p. 1620 - 1623 (2007/10/02)
The reaction of aryldiazonium tetrafluoroborates with acrylamide in a water-acetone mixture (1:2) in the presence of copper or iron salts and additives of thiocyanates (bromides, chlorides) of alkali metals and ammonium yields α-thiocyanato(bromo, chloro)-β-arylpropionamides. These compounds under the action of triethylamine easily eliminate hydrogen thiocyanate (bromide, chloride) with formation of β-arylacrylamides.
