7474-06-8

Basic information

• Product Name: 2-chloro-3-phenylpropanoic acid
• CAS NO: 7474-06-8
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.6196
• Mol File: 7474-06-8.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 305.8°C at 760 mmHg
• Flash Point: 138.7°C
• Density: 1.271g/cm³
• Vapor Pressure: 0.000351mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 2-chloro-3-phenylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-phenylpropanoic acid(7474-06-8)
• EPA Substance Registry System: 2-chloro-3-phenylpropanoic acid(7474-06-8)

Safety Data

• Hazardous Substances Data: 7474-06-8(Hazardous Substances Data)

Upstream product

• 109-95-5 ethyl nitrite 
• 150-30-1 Phenylalanine 
• 16503-53-0 2-bromo-3-phenylpropanoic acid 
• 17849-62-6 2-chloro-3-phenylpropionitrile 
• 38862-78-1 1,1-dichloro-3-phenylpropene 
• 50259-09-1 2-(1-chloro-2-phenyl-ethyl)-4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine 
• 81136-10-9 2-chloro-3-phenylpropanoic acid chloride 
• 62-53-3 aniline 
• 79-10-7 acrylic acid 
• 501-52-0 3-Phenylpropionic acid 
• 100-39-0 benzyl bromide 
• 29626-90-2 1-chloro-2-phenylethyl phenyl sulfoxide 
• 124-38-9 carbon dioxide 
• 27172-85-6 phenylalanine methyl ester hydrochloride 

Downstream Products

• 18166-56-8 α-chloro-β-phenylpropionamide 
• 120680-91-3 N-(3-phenyl-1-(R)-chloropropionyl)-phenylalanine 
• 1190832-61-1 C₁₅H₁₅ClN₂O 
• 7474-06-8 (S)-2-chloro-3-phenyl-propionic acid 
• 7474-06-8 (2R)-2-chloro-3-phenylpropionic acid 
• 59200-36-1 methyl (S)-2-chloro-3-phenylpropanoate 
• 7497-19-0 (S)-2-chloro-3-phenyl-propionic acid ethyl ester 
• 59200-36-1 methyl 2-chloro-3-phenylpropanoate 
• 1010685-60-5 C₁₄H₂₁Cl 

Relevant articles and documents

Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors

Extracellular virulence factors have emerged as attractive targets in the current antimicrobial resistance crisis. The Gram-negative pathogen Pseudomonas aeruginosa secretes the virulence factor elastase B (LasB), which plays an important role in the infection process. Here, we report a sub-micromolar, non-peptidic, fragment-like inhibitor of LasB discovered by careful visual inspection of structural data. Inspired by the natural LasB substrate, the original fragment was successfully merged and grown. The optimized inhibitor is accessible via simple chemistry and retained selectivity with a substantial improvement in activity, which can be rationalized by the crystal structure of LasB in complex with the inhibitor. We also demonstrate an improved in vivo efficacy of the optimized hit in Galleria mellonella larvae, highlighting the significance of this class of compounds as promising drug candidates.

A Straightforward Homologation of Carbon Dioxide with Magnesium Carbenoids en Route to α-Halocarboxylic Acids

The homologation of carbon dioxide with stable, (enantiopure) magnesium carbenoids constitutes a valuable method for preparing α-halo acid derivatives. The tactic features a high level of chemocontrol, thus enabling the synthesis of variously functionalized analogues. The flexibility to generate magnesium carbenoids through sulfoxide-, halogen- or proton- Mg exchange accounts for the wide scope of the reaction. (Figure presented.).

Di(1-naphthyl) methanol ester of carboxylic acids for absolute stereochemical determination

The absolute stereochemistry of chiral carboxylic acids is determined as a di(1-naphthyl)methanol ester derivative. Computational scoring of conformations favoring either P or M helicity of the naphthyl groups, capable of exciton-coupled circular dichroic coupling, leads to a predicted stereochemistry for the derivatized carboxylic acids.