81136-10-9

Upstream product

• 7474-06-8 2-chloro-3-phenylpropionic acid 
• 501-52-0 3-Phenylpropionic acid 
• 150-30-1 Phenylalanine 
• 16503-53-0 2-bromo-3-phenylpropanoic acid 
• 828-01-3 phenyllactic acid 
• 4530-18-1 2-(tert-butoxycarbonylamino)-3-phenylpropionic acid 
• 27172-85-6 phenylalanine methyl ester hydrochloride 

Downstream Products

• 20334-86-5 N-phenyl-2-chloro-3-phenylpropanamide 
• 87968-04-5 2-chloro-N,N-dimethyl-3-phenylpropanamide 
• 117770-84-0 N-(2-chloro-3-phenylpropionyl)tryptophan methyl ester 
• 18166-56-8 α-chloro-β-phenylpropionamide 
• 141734-77-2 (7S)-methyl 7-benzyl 1,3,4,5,6,7-hexahydro-6-oxopyrrolo<4,3,2-fg><3>benzazocine-4-carboxylate 
• 141734-77-2 (7R)-methyl 7-benzyl 1,3,4,5,6,7-hexahydro-6-oxopyrrolo<4,3,2-fg><3>benzazocine-4-carboxylate 
• 90004-75-4 DL-1-Chlor-1-brom-2-phenyl-ethan 
• 90560-55-7 DL-N-Brom-α-chlor-hydrozimtsaeure-amid 
• 1570274-33-7 2-chloro-N,N,3-triphenylpropanamide 
• 1570275-31-8 2-benzyl-N,N,4,4-tetraphenylbutanamide 
• 6632-27-5 2-chloro-N-(3-nitrophenyl)-3-phenylpropanamide 
• 1330781-99-1 6-(5-methyl-1H-pyrazol-4-yl)-2-(2-phenyl-1-pyrrolidin-1-ylethyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 7474-06-8 2-chloro-3-phenylpropionic acid 

Relevant academic research and scientific papers

Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl)alkylphosphonate esters

Unexpected substituent-dependent regioselectivty challenges in the synthesis of C-benzylated (N-arylcarbamoyl)phosphonate esters have been resolved. The C-benzylated N-furfurylcarbamoyl derivative showed low micromolar PfLDH inhibition, while one of the C-benzylated N-arylcarbamoyl analogues was active against Nagana Trypanosoma brucei parasites which are responsible for African trypanosomiasis in cattle.

HETEROCYCLIC COMPOUND

Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

Highly stereoselective synthesis of α-alkyl-α-hydroxycarboxylic acid derivatives catalyzed by a dinuclear zinc complex

A dinuclear zinc-ProPhenol catalyst enables highly enantioselective nitro-Michael reactions with oxazol-4(5H)-ones as nucleophilic substrates (see scheme, Nap=2-naphthyl). This work highlights the utility of the ProPhenol family of ligands. The modular nature of these ligands proved crucial in the optimization of reaction conditions to achieve excellent stereoselectivities. Copyright

Synthesis of 3,4-Bridged Indoles by Photocyclisation Reactions. Part 1. Photocyclisation of Halogenoacetyl Tryptophan Derivatives

Although irradiation of N-chloroacetyltryptophan results in a poor yield of photocyclisation to the indole 4-position due to competing cyclisation to C-2, the photocyclisation of (dichloroacetyl)tryptophan derivatives gives, after addition of a nucleophile in work-up, 7-substituted pyrrolobenzazocines in good yield and with trans-stereospecificity.N-(Trichloroacetyl)tryptophan derivatives also undergo photocyclisation to give 3,4-bridged indoles.The structures of the azocinoindoles 13, 21, 22 and 35, and the azepinoindole 15 were confirmed by X-ray crystallography.In one case the preparation of a cycloalkaindole was possible by the irradiation of the α-chloro amide of an indol-3-yl alkanoic acid.