88460-50-8

Upstream product

• 18167-15-2 3-hydroxy-2-phenylisoindolin-1-one 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 93-98-1 N-phenyl benzoyl amide 
• 140-88-5 ethyl acrylate 
• 520-03-6 N-phenylphthalimide 

Downstream Products

• 132869-05-7 4-Amino-2-(2-carboxyphenyl)quinoline Hydrochloride 
• 127935-29-9 6-(4-Benzyl-piperazin-1-ylmethyl)-isoindolo[2,1-a]quinoline-5,11-dione 
• 132868-93-0 6,6a-Dihydro-5-(phenoxycarbonyloxy)isoindolo<2,1-a>quinolin-11(5H)-one 
• 127935-25-5 6-(N-Methylbenzylaminomethyl)isoindolo<2,1-a>quinoline-5,11(5H)-dione 
• 127935-24-4 6-(Benzylaminomethyl)isoindolo<2,1-a>quinoline-5,11(5H)-dione 
• 127935-38-0 2,3-Dihydro-3-oxo-2-phenyl-1H-isoindole-1-acetyl Chloride 

Relevant academic research and scientific papers

Multicomponent Synthesis of Isoindolinones by RhIII Relay Catalysis: Synthesis of Pagoclone and Pazinaclone from Benzaldehyde

A practical one-pot isoindolinone synthesis enabled by RhIII catalysis was developed. The advantage of this protocol is that it does not require pre-preparation of amide substrates, because RhIII participates in two reactions independently. This mild, operationally multicomponent process transforms a wide variety of commercially available aldehydes into the corresponding γ-lactams in good yields, thereby demonstrating that N-pyridin-2-yl benzamide is an effective directing group. Notably, the anxiolytic drugs pagoclone and pazinaclone can be directly prepared by this methodology.

Non-coordinating-Anion-Directed Reversal of Activation Site: Selective C?H Bond Activation of N-Aryl Rings

An Rh-catalyzed selective C?H bond activation of diaryl-substituted anilides is described. In an attempt to achieve C?H activation of C-aryl rings, we unexpectedly obtained an N-aryl ring product under non-coordinating anion conditions, whereas the C-aryl

A Novel Synthesis of N-Substituted-3-carboethoxymethylphthalimidines

A novel synthesis of N-substituted-3-carboethoxymethylphthalimidines 5 is described from secondary benzamides.The benzamides 1 on lithiation with n-butyllithium followed by treatment with dimethylformamide furnish 3-hydroxyphthalimidines 2 in 74-84percent

Condensed pyrrolinone derivatives, their production and use

The compound of the formula STR1 wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH CH--CH CH--, --S--(CH 2) l --S--(l is an integer of 1 to 3), --N CH--CH N-- o