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Usage

Uses

Used in Food Industry:
4-METHYL-2-(1-PHENYL-ETHYL)-PHENOL is used as an antioxidant in the food industry to prevent the oxidation of fats and oils, thereby extending the shelf life of food products. It inhibits the formation of free radicals, which can cause rancidity and spoilage.
Used in Cosmetics Industry:
In the cosmetics industry, 4-METHYL-2-(1-PHENYL-ETHYL)-PHENOL is used as an antioxidant to protect products from oxidation, ensuring their stability and longevity. It helps maintain the quality and effectiveness of cosmetic products by preventing the degradation of active ingredients.
Used in Pharmaceutical Industry:
4-METHYL-2-(1-PHENYL-ETHYL)-PHENOL is used as an antioxidant in the pharmaceutical industry to protect medications from oxidation, which can lead to the degradation of active ingredients and reduce their therapeutic effectiveness. It helps maintain the quality and potency of medications, ensuring their safety and efficacy.
Used in Personal Care Products:
In personal care products, 4-METHYL-2-(1-PHENYL-ETHYL)-PHENOL is used as an antioxidant to protect products from oxidation, ensuring their stability and effectiveness. It helps maintain the quality of personal care products by preventing the degradation of active ingredients and extending their shelf life.
However, it is important to note that there is some controversy surrounding the safety of BHT, and its use is regulated in some countries due to potential health risks. As a result, manufacturers and consumers should be aware of the regulations and guidelines regarding the use of BHT in various applications.

InChI:InChI=1/C15H16O/c1-11-8-9-15(16)14(10-11)12(2)13-6-4-3-5-7-13/h3-10,12,16H,1-2H3

Upstream product

• 100-42-5 styrene 
• 106-44-5 p-cresol 
• 672-65-1 (1-chloroethyl)benzene 
• 201230-82-2 carbon monoxide 
• 62594-94-9 1-[(2-hydroxy-5-methyl)phenyl]-1-phenylethylene 
• 93-92-5 1-phenylethyl acetate 
• 536-74-3 phenylacetylene 
• 98-85-1 1-Phenylethanol 
• 614-34-6 p-cresyl benzoate 
• 1470-57-1 2-hydroxy-5-methylbenzophenone 
• 86608-97-1 2-(1-hydroxy-1-phenylethyl)-4-methylphenol 
• 98-88-4 benzoyl chloride 
• 53520-15-3 ((S)-1-phenyl-ethyl)-p-tolyl ether 
• 91-57-6 2-Methylnaphthalene 

Downstream Products

• 204975-79-1 2-hydroxy-5-methyl-3-(1-phenylethyl)benzaldehyde 
• 496866-13-8 (R)-2-hydroxy-5-methyl-3-(1-phenylethyl)benzaldehyde 
• 1582788-15-5 bis[4-methyl-2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(1-phenylethyl)phenoxy]titanium(IV) dichloride 

Relevant academic research and scientific papers

Catalytic synthesis of 4-methyl-2-(α-methyl benzyl) phenol over fe-al-mcm-41 for extraction-separation rubidium from brine

A new extractant 4-methyl-2-(α-methyl benzyl) phenol had been synthesized with styrene and p-cresol through the Friedel-Crafts alkylation reaction. Fe-Al-MCM-41 which was used as molecular sieves catalyst for the synthesis of the extractant was prepared by hydrothermal synthesis method and then characterized by FT-IR, XRD, NH3-TPD and N2 adsorption isotherm. The catalytic synthesis conditions of 4-methyl-2-(α-methyl benzyl) phenol such as reaction time, temperature and catalyst dosage were investigated. The conversion of styrene was about 81.2%, the target product yield and selectivity can reach 74.6% and 95.7% respectively. The structure of the 4-methyl-2-(α-methyl benzyl) phenol was confirmed by 1H-NMR. At the same time, 4-methyl-2-(α-methyl benzyl) phenol was used as extractant to separate rubidium from brine of which the rate of potassium to rubidium is 10:1 (CK+=10.0g/L, CRb+=1.0g/L). The experiment results show that the extractant has a great extraction performance to rubidium, the extraction yields of rubidium and potassium can reach 81.1% and 9.4% respectively. The separation factor of Rb+/K+ can reach up to 41.4.

ORGANIC COMPOUNDS

Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa.

Catalytic synthesis of 4-methyl-2-(α-methyl benzyl) phenol over fe-al-mcm-41 for extraction-separation rubidium from brine

A new extractant 4-methyl-2-(α-methyl benzyl) phenol had been synthesized with styrene and p-cresol through the Friedel-Crafts alkylation reaction. Fe-Al- MCM-41 which was used as molecular sieves catalyst for the synthesis of the extractant was prepared by hydrothermal synthesis method and then characterized by FT-IR, XRD, NH3-TPD and N2 adsorption isotherm. The catalytic synthesis conditions of 4- methyl-2-(α-methyl benzyl) phenol such as reaction time, temperature and catalyst dosage were investigated. The conversion of styrene was about 81.2%, the target product yield and selectivity can reach 74.6% and 95.7% respectively. The structure of the 4-methyl-2-(α-methyl benzyl) phenol was confirmed by 1H-NMR. At the same time, 4-methyl-2-(α-methyl benzyl) phenol was used as extractant to separate rubidium from brine of which the rate of potassium to rubidium is 10:1 (CK+=10.0g/L, CRb+=1.0g/L). The experiment results show that the extractant has a great extraction performance to rubidium, the extraction yields of rubidium and potassium can reach 81.1% and 9.4% respectively. The separation factor of Rb+/K+ can reach up to 41.4.

A simple Lewis acid induced reaction of phenols with electrophiles: Synthesis of functionalized 4H-chromenes and ortho-benzylphenols

Lewis acid ZnCl2 promoted cyclization protocol to 4H-chromenes is accomplished, using readily available phenols and acetophenones as starting materials. Interestingly, the process is feasible under the solvent free environment. Synthesis of a variety of 4H-chromenes have been accomplished using this strategy. In addition, this concept is extended to the synthesis of ortho-benzylphenols by treating phenols either with styrenes or secondary benzylic alcohols.

Hydroarylation of alkynes and alkenes through alumina-sulfuric acid catalyzed regioselective C–C bond formation

A highly atom-efficient synthetic protocol for hydroarylation of terminal-aryl alkynes and styrene through the regioselective C–C bond formation via the electrophilic addition of naphthols and substituted phenols has been developed using alumina-sulfuric acid as a heterogeneous supported solid acid catalyst. This methodology shows excellent regioselectivity and affords the desired product in good to excellent yield. The heterogeneous catalyst can also be recycled efficiently without much loss of activity.

HBF4- and AgBF4-Catalyzed ortho-Alkylation of Diarylamines and Phenols

A silver-tetrafluoroborate- or HBF4-catalyzed ortho-alkylation reaction of phenols and diarylamines with styrenes has been explored. A broad substrate scope is presented as well as mechanistic experiments and discussion.

Room Temperature Catalyst System for the Hydroarylation of Olefins

A simple protocol for the hydroarylation of olefins to yield diarylmethine products is described. A Friedel-Crafts-type synthetic strategy allows direct access to biorelevant products in high atom efficiency. A combination of substoichiometric amounts of TMSCl and ZnBr2 promotes a rapid hydroarylation process at ambient temperature. The method is high yielding and is amenable to scale-up protocols.

Iodoarene-Catalyzed Stereospecific Intramolecular sp3 C-H Amination: Reaction Development and Mechanistic Insights

A new strategy is reported for intramolecular sp3 C-H amination under mild reaction conditions using iodoarene as catalyst and m-CPBA as oxidant. This C-H functionalization involving iodine(III) reagents generated in situ occurs readily at sterically hindered tertiary C-H bonds. DFT (M06-2X) calculations show that the preferred pathway involves an iodonium cation intermediate and proceeds via an energetically concerted transition state, through hydride transfer followed by the spontaneous C-N bond formation. This leads to the experimentally observed amination at a chiral center without loss of stereochemical information.

H-β-zeolite-catalysed hydroarylation of styrenes

The hydroarylation of styrenes with various arene(heteroarene) compounds using H-β-zeolite as a green and recyclable heterogeneous catalyst under mild reaction conditions has been developed. The catalyst showed versatility and high selectivity (up to 100a€‰%) of desired 1,1-diarylalkanes in cyclohexane as solvent under the conditions studied. The catalyst could be reactivated by simple treatment with mineral acid at room temperature for better catalytic activity. Hydroarylation of styrenes with variousarene(heteroarene) compounds using H-β-zeolite as a green, heterogeneous and reusable catalyst under mild conditions is reported.

3D Nanoporous FeAl-KIT-5 with a cage type pore structure: A highly efficient and stable catalyst for hydroarylation of styrene and arylacetylenes

A novel bimetallic nanoporous FeAl-KIT-5 catalyst with a cage type porous structure and a high surface area has been prepared for the hydroarylation of styrene and arylacetylenes to afford 1,1-diarylalkanes and 1,1-diarylalkenes, respectively. The catalyst was found to be highly active, and selective, affording a high yield of substituted alkanes and alkenes. The catalyst also showed much higher activity as compared to those of other nanoporous catalysts such as AlSBA-15, AlKIT-5, and FeKIT-5, and can be reused several times without much loss of its activity.