181711-43-3

Basic information

• Product Name: 2-((4-fluorophenyl)(hydroxy)methyl)phenol
• CAS NO: 181711-43-3
• Molecular Weight: 218.228
• Mol File: 181711-43-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-((4-fluorophenyl)(hydroxy)methyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-fluorophenyl)(hydroxy)methyl)phenol(181711-43-3)
• EPA Substance Registry System: 2-((4-fluorophenyl)(hydroxy)methyl)phenol(181711-43-3)

Safety Data

• Hazardous Substances Data: 181711-43-3(Hazardous Substances Data)

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 90-02-8 salicylaldehyde 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 1422447-32-2 4-fluoro-2-((4-methoxyphenyl)(tosyl)methyl)phenol 
• 401-30-9 2-(4-fluorobenzyl)phenol 
• 62666-37-9 (2-hydroxyphenyl)(4-fluorophenyl)methanone 

Relevant articles and documents

NOVEL THYROMIMETICS

Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, X1, X2, Q, R1, R2 and n are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.

Catalytic Asymmetric Three-component Hydroacyloxylation/ 1,4-Conjugate Addition of Ynamides

A highly enantioselective three-component hydroacyloxylation/1,4-conjugate addition of ortho-hydroxybenzyl alcohols, ynamides and carboxylic acids was developed under mild reaction conditions in the presence of a chiral N,N′-dioxide/Sc(OTf)3 complex, which went through in situ generated ortho-quinone methides with α-acyloxyenamides, delivering a range of corresponding chiral α-acyloxyenamides derivatives containing gem(1,1)-diaryl skeletons in moderate to good yields with excellent ee values. The scale-up experiment and further derivation showed the practicality of this catalytic system. In addition, a possible catalytic cycle and transition state model was proposed to elucidate the origin of the stereoselectivity based on X-ray crystal structure of the α-acyloxyenamide intermediate and product.

Organocatalytic Asymmetric Domino Michael/Acyl Transfer Reaction Between α-Nitroketones and in situ-Generated ortho-Quinone Methides: Route to 2-(1-Arylethyl)phenols

An organocatalytic asymmetric domino Michael/acyl transfer reaction between α-nitroketones and o-quinone methides is disclosed. o-Quinone methides are generated in situ from 2-sulfonylmethylphenols in basic medium. With 10 mol% of bifunctional squaramide catalyst, high yields and excellent enantioselectivities are achieved for a variety of O-acyl 2-(1-arylethyl)phenols under mild reaction condition. (Figure presented.).