18175-34-3

Basic information

• Product Name: 4-Piperidinol, 2-[(4-methoxyphenyl)methyl]-3,4-dimethyl-
• Synonyms: 2-(p-methoxybenzyl)-3,4-dimethyl-4-hydroxy-piperidine;2-(4-methyoxybenzyl)-3,4-dimethyl-4-hexahydropyridine
• CAS NO: 18175-34-3
• Molecular Formula: C15H23NO2
• Molecular Weight: 249.353
• Mol File: 18175-34-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-Piperidinol, 2-[(4-methoxyphenyl)methyl]-3,4-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinol, 2-[(4-methoxyphenyl)methyl]-3,4-dimethyl-(18175-34-3)
• EPA Substance Registry System: 4-Piperidinol, 2-[(4-methoxyphenyl)methyl]-3,4-dimethyl-(18175-34-3)

Safety Data

• Hazardous Substances Data: 18175-34-3(Hazardous Substances Data)

Upstream product

• 21589-37-7 3-Methyl-penten-2-yl-amin 
• 16546-01-3 ethyl 3-(4-methoxyphenyl)-2,3-epoxypropionate 
• 1187-81-1 5-chloro-3-methylpentane-2-one 
• 1123-19-9 3-acetyl-3-methyl-dihydro-furan-2-one 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 42245-42-1 methyl 3-(4-methoxyphenyl)glycidate 
• 75540-48-6 2-((E)-3-Methyl-pent-3-enyl)-isoindole-1,3-dione 
• 90667-54-2 N-(3-methyl-3-pentenyl)phthalimide 
• 57253-31-3 (E)-5-bromo-3-methylpentyl-2-ene 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 59444-75-6 1-tetrahydrofurfuryl-2-(p-methoxybenzyl)-3,4-dimethyl-4-hydroxy-piperidine 
• 359-83-1 pentazocin 

Relevant articles and documents

Method for preparing pentazocine intermediate

The invention belongs to the technical field of chemical synthesis and provides a method for preparing a pentazocine intermediate. The method comprises the following steps of: under the catalysis of raney nickel, mixing an alcoholic solution of ammonia gas with the mass content of 5-30% with a reaction raw material containing a compound XV (3-methyl-3-pentenenitrile); carrying out a reduction reaction by taking hydrogen as a reducing agent; and reducing the reaction raw material containing the compound XV into a reaction product containing a compound XVI II (3-methyl-3-pentenenamine). According to the method disclosed by the invention, the alcoholic solution of ammonia gas with a certain concentration is added in the hydrogen reduction process, so that the reaction pressure and the reaction temperature are greatly reduced, and meanwhile, the reaction time is greatly shortened. Under the combined condition, the feeding amount of the catalyst raney nickel is relatively small, and industrial production is facilitated.

Preparation method of pentazocine intermediate

The invention discloses a preparation method of a pentazocine intermediate and belongs to the technical field of chemical synthesis. A compound 11, namely the prepared pentazocine intermediate, is obtained through a methylation reaction, a ring-opening reaction, a reduction reaction, a protection reaction, a substitution-reduction reaction, an esterification reaction, an elimination reaction, a hydrazinolysis reaction, a ring-closing reaction and a condensation-demethylation reaction. The problems of low yield and resource waste in existing pentazocine preparation methods are solved, the current situation that industrial production is difficult to realize due to use of explosion substances and high pressure condition is eliminated, the key intermediate is obtained with a simple method, themethod is high in yield, simple in process and applicable to industrial production, resources are saved, and the production cost is reduced.