18181-05-0

Basic information

• Product Name: (2R,3S)-3-Hydroxy-N,N-dimethyl-2,3-diphenyl-propionamide
• CAS NO: 18181-05-0
• Molecular Weight: 269.343
• Mol File: 18181-05-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,3S)-3-Hydroxy-N,N-dimethyl-2,3-diphenyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-3-Hydroxy-N,N-dimethyl-2,3-diphenyl-propionamide(18181-05-0)
• EPA Substance Registry System: (2R,3S)-3-Hydroxy-N,N-dimethyl-2,3-diphenyl-propionamide(18181-05-0)

Safety Data

• Hazardous Substances Data: 18181-05-0(Hazardous Substances Data)

Upstream product

• 18925-69-4 N,N-dimethyl-2-phenylacetamide 
• 100-52-7 benzaldehyde 
• 93-58-3 benzoic acid methyl ester 

Downstream Products

• 18456-33-2 (+/-)-threo-3-Dimethylamino-1,2-diphenyl-propanol-⁽¹⁾ 
• 18456-33-2 (+/-)-erythro-3-Dimethylamino-1,2-diphenyl-propanol-⁽¹⁾ 

Relevant articles and documents

Manganese-Catalyzed anti-Selective Asymmetric Hydrogenation of α-Substituted β-Ketoamides

A Mn-catalyzed diastereo- and enantioselective hydrogenation of α-substituted β-ketoamides has been realized for the first time under dynamic kinetic resolution conditions. anti-α-Substituted β-hydroxy amides, which are useful building blocks for the synthesis of bioactive molecules and chiral drugs, were prepared in high yields with excellent selectivity (up to >99 percent dr and >99 percent ee) and unprecedentedly high activity (TON up to 10000). The origin of the excellent stereoselectivity was clarified by DFT calculations.