181863-36-5

Upstream product

• 144-62-7 oxalic acid 
• 95-92-1 oxalic acid diethyl ester 
• 534-85-0 N-phenyl-1,2-benzenediamine 

Downstream Products

• 181863-42-3 3-chloro-1-phenylquinoxalin-2(1H)-one 

Relevant academic research and scientific papers

Green synthesis method of N-substituted-1,4-dihydro-2,3-quinoxalinedione compound

The invention discloses a green synthesis method of an N-substituted-1,4-dihydro-2,3-quinoxalinedione compound. The green synthesis method comprises the following steps: reacting ammonium persulfate with an N-substituted quinoxaline-2(1H)-one derivative in an aqueous solution of DL-alpha-tocopherol methoxy polyethylene glycol succinic acid water to generate the N-substituted-1,4-dihydro-2,3-quinoxalinedione compound; and after the reaction is finished, extracting a reaction product by using ethyl acetate, and performing vacuum drying to obtain the high-purity target product. The aqueous solution of the DL-alpha-tocopherol methoxy polyethylene glycol succinic acid can be recycled at least five times or more. The method is good in product selectivity, high in yield, simple in separation process, low in raw material cost, friendly to environment and beneficial for industrial production and application.

Metal-Free C3 Hydroxylation of Quinoxalin-2(1H)-ones in Water

A practical protocol for the preparation of quinoxaline-2,3(1H,4H)-diones through direct C(sp2)?H hydroxylation of quinoxalin-2(1H)-ones in recyclable DL-α-Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) (TPGS-750-M/H

A new facile, efficient synthesis and structure peculiarity of quinoxaline derivatives with two benzimidazole fragments

A highly efficient and versatile method for the synthesis of quinoxaline derivatives with two benzimidazole fragments have been developed on the basis of the ring contraction of 3-(benzimidazo-2-yl)quinoxalin-2(1H)-one with 1,2-diaminobenzene and its various types of substituted and condensed derivatives. Owing to the inter- and intramolecular processes, involving self association, proton exchange, conformational, and/or tautomeric exchanges between several forms for most of the bis-benzimidazolylquinoxalines signals of bridged and neighboring carbon atoms and the hydrogen atoms of the neighboring carbon atoms of benzimidazole fragments in the NMR spectra are broadened. The conjugation between the benzimidazole fragments and the quinoxaline core of the molecules is increased from the quinoxaline derivative (10c) to its thiadiazol[f]- (17) and pyrrolo[a]-(19) annulated derivatives, resulting in a greater planarity of the molecule as a whole.

From byproducts to efficient fluorophores: A route to the synthesis of fluorubines

The reaction of bis(imidoyl) chlorides of oxalic acid with monoalkyl hydrazines leads to substituted ?2-l,2diazetines, which are versatile building blocks for ring-transformation reactions. One remarkable product originating from side reactions featured by a strong orange/red fluorescence was confirmed as a novel fluorubine derivative. In continuing our studies to substituted oligoazaacenes, we developed several synthetic entries to build up novel fluorubine derivatives, in which particularly aminobridged bis(quinoxaline)s are the key products for cationic hexaazapentacenes. We would like to discuss the possible formation pathways of these fluorubine derivatives, which exhibit interesting photophysical and chemical properties. The structures of all new derivatives were confirmed by common analytical methods (NMR spectroscopy, CV, U V/Vis, mass spectrometry, elemental analysis, and X-ray structural analysis) and will be discussed on selected examples in more detail.