181863-36-5

Basic information

• Product Name: 1-phenylquinoxaline-2,3(1H,4H)-dione
• Synonyms: 1-phenylquinoxaline-2,3(1H,4H)-dione
• CAS NO: 181863-36-5
• Molecular Formula: C₁₄H₁₀N₂O₂
• Molecular Weight: 238.24
• Mol File: 181863-36-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-phenylquinoxaline-2,3(1H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenylquinoxaline-2,3(1H,4H)-dione(181863-36-5)
• EPA Substance Registry System: 1-phenylquinoxaline-2,3(1H,4H)-dione(181863-36-5)

Safety Data

• Hazardous Substances Data: 181863-36-5(Hazardous Substances Data)

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 534-85-0 N-phenyl-1,2-benzenediamine 
• 144-62-7 oxalic acid 

Downstream Products

• 181863-42-3 3-chloro-1-phenylquinoxalin-2(1H)-one 

Relevant articles and documents

Green synthesis method of N-substituted-1,4-dihydro-2,3-quinoxalinedione compound

The invention discloses a green synthesis method of an N-substituted-1,4-dihydro-2,3-quinoxalinedione compound. The green synthesis method comprises the following steps: reacting ammonium persulfate with an N-substituted quinoxaline-2(1H)-one derivative in an aqueous solution of DL-alpha-tocopherol methoxy polyethylene glycol succinic acid water to generate the N-substituted-1,4-dihydro-2,3-quinoxalinedione compound; and after the reaction is finished, extracting a reaction product by using ethyl acetate, and performing vacuum drying to obtain the high-purity target product. The aqueous solution of the DL-alpha-tocopherol methoxy polyethylene glycol succinic acid can be recycled at least five times or more. The method is good in product selectivity, high in yield, simple in separation process, low in raw material cost, friendly to environment and beneficial for industrial production and application.

A new facile, efficient synthesis and structure peculiarity of quinoxaline derivatives with two benzimidazole fragments

A highly efficient and versatile method for the synthesis of quinoxaline derivatives with two benzimidazole fragments have been developed on the basis of the ring contraction of 3-(benzimidazo-2-yl)quinoxalin-2(1H)-one with 1,2-diaminobenzene and its various types of substituted and condensed derivatives. Owing to the inter- and intramolecular processes, involving self association, proton exchange, conformational, and/or tautomeric exchanges between several forms for most of the bis-benzimidazolylquinoxalines signals of bridged and neighboring carbon atoms and the hydrogen atoms of the neighboring carbon atoms of benzimidazole fragments in the NMR spectra are broadened. The conjugation between the benzimidazole fragments and the quinoxaline core of the molecules is increased from the quinoxaline derivative (10c) to its thiadiazol[f]- (17) and pyrrolo[a]-(19) annulated derivatives, resulting in a greater planarity of the molecule as a whole.