181941-59-3

Upstream product

• 181941-63-9 ethyl 1-{5-oxo-1-[(S)-1-phenylethyl]-2,5-dihydro-1H-pyrrol-3-yl}cyclopropanecarboxylate 
• 503603-89-2 ethyl 1-{(3S)-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate 
• 181941-61-7 ethyl 3-(1-ethoxycarbonylcyclopropan-1-yl)-3-hydroxybutanoate 
• 181941-62-8 ethyl (E)-3-(1-ethoxycarbonylcyclopropan-1-yl)-2-butenoate 
• 503603-90-5 ethyl 1-[(3S)-1-benzyloxycarbonylpyrrolidin-3-yl]cyclopropanecarboxylate 
• 190954-59-7 ethyl 1-{(3S)-5-oxo-1-[(S)-1-phenylethyl]pyrrolidin-3-yl}cyclopropanecarboxylate 
• 181941-65-1 ethyl 1-{(3S)-1-[(S)-1-phenylethyl]-5-thioxopyrrolidin-3-yl}cyclopropanecarboxylate 

Downstream Products

• 181941-67-3 (3R)-1-benzyloxycarbonyl-3-[1-(N-tert-butoxycarbonyl-N-ethyl)aminocyclopropyl]pyrrolidine 
• 181941-66-2 1-benzyloxycarbonyl-3-(R)-[1-(N-(tert-butoxycarbonyl)-N-(methyl)amino]cyclopropyl]pyrrolidine 

Relevant academic research and scientific papers

DEHALOGENO COMPOUNDS

3-(1-Aminocycloalkyl)pyrrolidinyl-substituted-6-dehalodeno(hydrogen-substituted)quinolon carboxylic acid derivatives having specific substitunets as represented by the following formula (I), its salts, and hydrates thereof exhibit a broad and potent antibacterial activity on gram-negative and gram-positive bacteria, in particular, resistant bacteria typified by gram-positive cocci, including MRSA, PRSP and VRE . Thus these compounds are usable as drugs.

Synthesis and structure - Activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8- methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents

A series of novel 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolones bearing fluorinated (3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl substituents at the C-7 position (2-4) was synthesized to obtain potent drugs for infections cau

Pyridonecarboxylic acid derivatives substituted by a bicyclic amino group as antibacterials

This invention relates to a N1 -(halogenocyclopropyl)-substituted pyridonecarboxylic acid derivative represented by the following formula (I): STR1 wherein X1 is a halogen atom or a hydrogen atom; X2 is a halogen atom; R1 is a hydrogen atom, a hydroxyl group, a thiol group, a halogenomethyl group, an amino group, an alkyl group or an alkoxy group which may have a substituent group; R2 is a group represented by the following formula (II): STR2 wherein R3 and R4 are independently a hydrogen atom or an alkyl group and n is an integer of 1 or 2; A is a nitrogen atom or a partial structure of the following formula (III): STR3 wherein X3 is a hydrogen atom, a halogen atom, a cyano group, an amino group, an alkyl group, a halogenomethyl group, an alkoxyl group or a halogenomethoxyl group which may have a substituent group; and R is a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidynyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, a 3-acetoxy-2-oxobutyl group, an alkyl group, an alkoxymethyl group or a phenylalkyl group, and provides a heterocyclic compound useful as antibacterial drugs.