182007-01-8

Basic information

• Product Name: bis(5-tert-butyl-2-methoxyphenyl)methanol
• Synonyms: bis(5-tert-butyl-2-methoxyphenyl)methanol
• CAS NO: 182007-01-8
• Molecular Weight: 356.505
• Mol File: 182007-01-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: bis(5-tert-butyl-2-methoxyphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: bis(5-tert-butyl-2-methoxyphenyl)methanol(182007-01-8)
• EPA Substance Registry System: bis(5-tert-butyl-2-methoxyphenyl)methanol(182007-01-8)

Safety Data

• Hazardous Substances Data: 182007-01-8(Hazardous Substances Data)

Upstream product

• 41280-65-3 2-bromo-4-tert-butylanisole 
• 85943-26-6 5-tert-butyl-2-methoxybenzaldehyde 

Downstream Products

• 25446-98-4 2,2'-dihydroxy-5,5'-di-tert-butylbenzophenone 
• 98085-85-9 bis(5-tert-butyl-2-methoxyphenyl)methanone 
• 98085-84-8 2,2'-Dimethoxy-5,5'-di-tert-butyldiphenylmethane 

Relevant articles and documents

Complete chiral induction from enantiopure 1,2-diamines to benzophenone-based achiral bisphosphane ligands in noyori-type RuII catalysts

We report the design and synthesis of a novel class of RuII catalysts (3) composed of achiral benzophenone-based bisphosphane ligands and enantiopure 1,2-diamines for the asymmetric hydrogenation of aryl ketones. The developed catalysts show excellent enantioselectivities (up to 97 % ee) and activities (up to S/C = 10,000) in the hydrogenation of a variety of aromatic ketones. Complete chiral induction from the enantiopure 1,2-diamine to the achiral bisphosphane ligand was observed. The coordination of the C=O moiety in 3 to the cationic RuII center is considered to be of key importance in providing a higher thermodynamic and kinetic rotation barrier for the flexible bisphosphane ligand, resulting in the preferential formation of only one diastereomer, and thus explaining the high enantioselectivity of the catalyst. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.