25446-98-4

Basic information

• Product Name: Methanone, bis[5-(1,1-dimethylethyl)-2-hydroxyphenyl]-
• Synonyms: bis(5-t-butyl-2-hydroxyphenyl)ketone;5,5'-Di-tert-butyl-2,2'-dihydroxy-benzophenon;Methanone,bis[5-(1,1-dimethylethyl)-2-hydroxyphenyl]
• CAS NO: 25446-98-4
• Molecular Formula: C21H26O3
• Molecular Weight: 326.436
• Mol File: 25446-98-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 104-106°C
• CAS DataBase Reference: Methanone, bis[5-(1,1-dimethylethyl)-2-hydroxyphenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, bis[5-(1,1-dimethylethyl)-2-hydroxyphenyl]-(25446-98-4)
• EPA Substance Registry System: Methanone, bis[5-(1,1-dimethylethyl)-2-hydroxyphenyl]-(25446-98-4)

Safety Data

• Hazardous Substances Data: 25446-98-4(Hazardous Substances Data)

Usage

Preparation

obtained by photo-Fries rearrangement of p-tert-butylphenyl carbonate,in ethanol for 24 h (26%) ;in benzene for 24 h (36%) ;in ethylene dichloride, where the rearrangement proceeds via the for-mation of an intermediate ester, the p-tert-butylphenyl 5-tert-butylsalicylate.

Upstream product

• 214354-68-4 5-tert-butyl-3-[5-tert-butyl-2-hydroxyphenyl]-2-keto-2,3-dihydrobenzofuran 
• 85943-26-6 5-tert-butyl-2-methoxybenzaldehyde 
• 182007-01-8 bis(5-tert-butyl-2-methoxyphenyl)methanol 
• 41280-65-3 2-bromo-4-tert-butylanisole 
• 98085-85-9 bis(5-tert-butyl-2-methoxyphenyl)methanone 
• 149790-47-6 Acetic acid 2-(2-acetoxy-5-tert-butyl-benzyl)-4-tert-butyl-phenyl ester 
• 799-13-3 bis(5-tert-butyl-2-hydroxyphenyl)methane 
• 149790-52-3 Acetic acid 2-(2-acetoxy-5-tert-butyl-benzoyl)-4-tert-butyl-phenyl ester 

Downstream Products

• 182310-73-2 {5-tert-Butyl-3-[5-tert-butyl-3-(5-tert-butyl-2-hydroxy-benzyl)-2-hydroxy-benzyl]-2-hydroxy-phenyl}-{5-tert-butyl-3-[5-tert-butyl-3-(5-tert-butyl-2-hydroxy-3-hydroxymethyl-benzyl)-2-hydroxy-benzyl]-2-hydroxy-phenyl}-methanone 
• 182310-69-6 Bis-{5-tert-butyl-3-[5-tert-butyl-3-(5-tert-butyl-2-hydroxy-benzyl)-2-hydroxy-benzyl]-2-hydroxy-phenyl}-methanone 
• 182310-66-3 Bis-[5-tert-butyl-3-(5-tert-butyl-2-hydroxy-3-hydroxymethyl-benzyl)-2-hydroxy-phenyl]-methanone 
• 182310-71-0 [5-tert-Butyl-3-(5-tert-butyl-2-hydroxy-benzyl)-2-hydroxy-phenyl]-[5-tert-butyl-3-(5-tert-butyl-2-hydroxy-3-hydroxymethyl-benzyl)-2-hydroxy-phenyl]-methanone 
• 149790-91-0 4-t-butyl-2-<5-t-butyl-3-<5-t-butyl-3-(5-t-butylsalicyl)salicyloyl>salicyl>phenol 
• 149790-66-9 2-bromo-4-t-butyl-6-<5-t-butyl-3-<5-t-butyl-3-(5-t-butylsalicyloyl)salicyl>salicyloyl>phenol 
• 149826-78-8 4-t-butyl-2-(5-t-butyl-3-chloromethylsalicyloyl)-6-chloromethylphenol 

Relevant articles and documents

Diastereo- And Atroposelective Synthesis of Bridged Biaryls Bearing an Eight-Membered Lactone through an Organocatalytic Cascade

We present herein an unprecedented stereoselective synthesis of bridged biaryls with defined axial and central chirality from readily available starting materials. This N-heterocyclic carbene-catalyzed method proceeds through propargylic substitution of azolium enolates followed by two-directional cyclization, as supported by DFT calculation. A range of benzofuran/indole-derived bridged biaryls bearing an eight-membered lactone are accessed with uniformly high stereoselectivity (>98:2 dr, mostly >98% ee).

Preparation method of 2,2'-dyhydroxy benzophenone compound

The invention relates to a preparation method of a 2,2'-dyhydroxy benzophenone compound, and belongs to the technical field of synthesis of ketone acyclic compounds. 2,2-di(2-hydroxy-5-alkylphenyl)methyl acetate is taken as a raw material, an anhydrous base catalyst is added after the raw material is dissolved in a solvent, oxygen or air is injected to conduct an oxidation reaction, and the compound is prepared. The preparation method is applied to preparation of the dyhydroxy benzophenone compound, and has the advantages that the steps are easy and simple, the synthesis process is green and free of pollution, and the yield is high.

Synthesis and Inclusion Properties of Carbonyl-Bridged Analogs of Acyclic p-t-Butylphenol-Formaldehyde Oligomers

A series of compounds in which a part or all of the methylene bridges of acyclic p-t-butylphenol-formaldehyde oligomers are replaced by C=O bridge(s) has been synthesized.The carbonyl-bridged tetramers, except for that with no methylene bridge, formed crystalline host-guest complexes with various organic compounds; those with two C=O bridges were superior regarding complexation, regardless of the position of the bridges.Exclusive guest selectivity of the tetramer with one terminal C=O bridge was observed for benzene and its methyl derivatives in a two-component system.The fully carbonyl-bridged dimer, trimer, tetramer, and pentamer had no complexing-capability.The thermal stability of benzene complexes (host : guest = 2 : 1) of the tetramers with one C=O bridge, as estimated from their thermal dissociation rates, are remarkably lower than that of the parent tetramer.Oximes derived from the tetramers with one C=O bridge were much more effective than the corresponding carbonyl-bridged ones regarding their complex-forming capability.