182056-39-9

Basic information

• Product Name: 2-Bromo-4-iodoanisole
• Synonyms: 2-Bromo-4-iodoanisole;2-Bromo-4-iodo-1-methoxybenzene, 2-Bromo-4-iodophenyl methyl ether
• CAS NO: 182056-39-9
• Molecular Formula: C₇H₆BrIO
• Molecular Weight: 312.93041
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Iodine Compounds
• Mol File: 182056-39-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 80-82 °C(Solv: hexane (110-54-3); toluene (108-88-3))
• Boiling Point: 285.1±30.0 °C(Predicted)
• Appearance: /
• Density: 2.062±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-Bromo-4-iodoanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-iodoanisole(182056-39-9)
• EPA Substance Registry System: 2-Bromo-4-iodoanisole(182056-39-9)

Safety Data

• Hazardous Substances Data: 182056-39-9(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-iodoanisole is a chemical compound with the molecular formula C7H6BrIO. It is a halogenated aromatic compound that is commonly used in organic synthesis and pharmaceutical research. 2-Bromo-4-iodoanisole is often used as an intermediate in the production of various pharmaceuticals, agrochemicals, and other organic compounds. It is known for its strong halogenation properties, making it useful for introducing bromine and iodine atoms into other molecules. 2-Bromo-4-iodoanisole is also used in the preparation of various biologically active compounds and materials for research purposes. Additionally, 2-Bromo-4-iodoanisole has potential applications in the field of medicinal chemistry for the development of new therapeutic agents.

InChI:InChI=1S/C7H6BrIO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,1H3

Upstream product

• 19056-41-8 3-bromo-p-anisidine 
• 696-62-8 para-iodoanisole 
• 540-38-5 p-Iodophenol 
• 133430-98-5 2-bromo-4-iodo-phenol 
• 74-88-4 methyl iodide 
• 578-57-4 2-bromoanisole 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 1260376-34-8 (E)-N-(3-bromo-4-hydroxyphenethyl)-3-(3-bromo-4-methoxyphenyl)acrylamide 
• 1110659-40-9 (E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide 
• 1260376-32-6 (E)-3-(3-bromo-4-methoxyphenyl)-N-(4-hydroxyphenethyl)acrylamide 
• 1260376-39-3 3,3-bis(3-bromo-4-methoxyphenyl)-N-(4-hydroxyphenethyl)acrylamide 
• 56341-31-2 2-bromo-9H-xanthene-9-one 
• 1431304-49-2 N-(3-bromo-4-methoxyphenyl)methanesulfonamide 

Relevant articles and documents

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THERAPY

The invention addresses radioresistance in cancer treatment involving radiotherapy and, in particular, limitations associated with the use of the drug sulfasalazine. Specifically, it provides a series of compounds for use as radiosensitizers in the treatment of cancers such as glioblastomas which are lethal and inherently resistant to radiotherapy, in one embodiment, the invention provides compounds of general formula (I), their stereoisomers and pharmaceutically acceptable salts for use as radiosensitizers in the treatment of cancer wherein ring A is selected from optionally substituted phenyl, biphenyl and fluorenyl; each X is independently selected from: -C1-6 alkyl (preferably C1-3 alkyl, e.g. -CH3), -O-C1-6 alkyl (preferably -O-C1-3 alkyl, e.g, -OCH3), -S-C1-6 alkyl (preferably -S-C1-3 alkyl, e.g, -SCH3), -OH, -SH, -CO2R1 (where R1 is H or C1-6 alkyl, preferably C1-3 alkyl, e.g. -CH3), -SO2-C1-6 alkyl (preferably -SO2-C1-3 alkyl, e.g. -SO2-CH3), -SO2-NR2R3 (where R2 is H and R3 is optionally substituted phenyl), -NR4R5 (wherein R4 and R5 are independently selected from H, C1-6 alkyl (preferably C1-3 alkyl, e.g. -CH3), and -CO-C1-6 alkyl (preferably -CO-C1-3 alkyl, e.g. -CO-CH3), halogen (e.g. F, Cl or Br), and optionally substituted tetrazolyl; n is an integer from 0 to 5, preferably 0 to 2, e.g. 1 or 2; and denotes an E or Z double bond.

Air-Stable Blue Phosphorescent Tetradentate Platinum(II) Complexes as Strong Photo-Reductant

Strong photo-reductants have applications in photo-redox organic synthesis involving reductive activation of C?X(halide) and C=O bonds. We report herein air-stable PtII complexes supported by tetradentate bis(phenolate-NHC) ligands having peripheral electron-donating N-carbazolyl groups. Photo-physical, electrochemical, and computational studies reveal that the presence of N-carbazolyl groups enhances the light absorption and redox reversibility because of its involvement into the frontier MOs in both ground and excited states, making the complexes robust strong photo-reductant with E([Pt]+/*) over ?2.6 V vs. Cp2Fe+/0. The one-electron reduced [Pt]? species are stronger reductants with EPC([Pt]0/?) up to ?3.1 V vs. Cp2Fe+/0. By virtue of the strong reducing nature of these species generated upon light excitation, they can be used in light-driven reductive coupling of carbonyl compounds and reductive debromination of a wide range of unactivated aryl bromides.