182067-63-6

Usage

Structure

Cyclic derivative of piperazine with three methyl groups attached to the nitrogen atoms

Physical properties

White crystalline solid, molecular weight of 156.18 g/mol

Uses

Primarily used as an intermediate in the synthesis of pharmaceutical drugs

Industry applications

Potential applications in the pharmaceutical and chemical industries due to its versatile reactivity and structural properties

Biological activity

May possess some biological activity and could be of interest in medicinal chemistry research

Upstream product

• 865879-17-0 benzyl N-[N-t-butoxycarbonylsarcosyl]-2-benzyloxycarbonylglycinate 
• 519141-14-1 3-benzyloxycarbonyl-1,3,4-trimethylpiperazine-2,5-dione 
• 519141-10-7 3-benzyloxycarbonyl-1,3-dimethylpiperazine-2,5-dione 
• 519141-04-9 3-benzyloxycarbonyl-1,4-dimethylpiperazine-2,5-dione 
• 519141-03-8 1-methyl-3-benzyloxycarbonylpiperazine-2,5-dione 
• 4526-77-6 3-methylpiperazine-2,5-dione 
• 74-88-4 methyl iodide 
• 108584-33-4 N-(2-bromo-propionyl)-N-methyl-glycine 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF

The present invention relates to an epidithiodioxopiperazine derivative represented by the Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mim

Multi-purpose functionality for the structural elaboration of the piperazine-2,5-dione motif

Mild methods for controlled C- and N-alkylation of 3-benzyloxycarbonylpiperazine-2,5-diones are reported. The benzyloxylcarbonyl substituent can also serve as latent functionality for N-acyliminium ion formation and subsequent trapping enables installation of new carbon and/or heteroatom substituents.

Selectivity in radical reactions of alanylglycine anhydride derivatives

Functionalization of N,N′-disubstituted alanylglycine anhydrides under radical conditions is described. The radical (7), generated (i) from reactions of N,N′-disubstituted alanylglycine anhydrides with N-bromosuccinimide, and (ii) from related bromo compounds by reaction with tributyltin deuteride, undergoes carbon-bromine and carbon-deuterium bond formation with moderate to high diastereoselectivities depending on the N-substituents present.