182073-75-2

Upstream product

• 1201928-26-8 methyl (+/-)-1-(2,4-dimethoxyphenyl)methyl-4-methylene-5-oxo-2-pyrrolidinecarboxylate 
• 131320-33-7 dimethyl (+/-)-4-methyleneglutamate hydrochloride 
• 67-56-1 methanol 
• 181826-71-1 (S)-5-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-3-methylene-pyrrolidin-2-one 
• 181826-69-7 (S)-1-Benzyloxy-5-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-3-methylene-pyrrolidin-2-one 
• 181826-59-5 (S)-4-Benzyloxyamino-5-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-methylene-5-oxo-pentanoic acid methyl ester 
• 75-77-4 chloro-trimethyl-silane 
• 1201928-22-4 methyl (S)-(+)-1-[(2,4-dimethoxyphenyl)methyl]-4-methylene-5-oxo-2-pyrrolidinecarboxylate 
• 61541-27-3 methyl (+/-)-4-methylene 5-oxo-pyrrolidin-2-carboxylate 

Downstream Products

• 1224433-46-8 (S)-(+)-4-methylene-5-oxo-pyrrolidine-2-carboxylic acid 
• 1201928-31-5 (R)-(-)-4-methylene-5-oxo-pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

Chemoenzymatic synthesis of optically active α-methylene-γ-carboxy-γ-lactams and γ-lactones

Three α-methylene-γ-carbomethoxy-γ-butyrolactams (methyl α-methylene-pyroglutamates) 11, 12 and 13, differing in the substitution at the heterocyclic nitrogen, as well as the structurally related γ-lactones 14 and 15 were synthesised and resolved enzymati

The asymmetric synthesis of allylglycine and other unnatural α-amino acid via zinc-mediated allylation of oximes in aqueous media

Enantiomerically pure or highly enriched allylglycine and its chain-substituted analogs are easily accessible from the reaction of the sultam derivative of O-benzyl glyoxylic acid oxime with allylic bromides in the presence of powdered zinc in aqueous ammonium chloride.